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Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix

The aim of this study was to investigate the effects of the physical properties (diameter size, powder particle size, composition of bark- and wood-tissue, and turnover rate) and processing methods on the content of active ingredients in Astragali radix (AR), a popular Chinese herbal medicine. The a...

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Autores principales: Chien, Mei-Yin, Yang, Chih-Min, Chen, Chao-Hsiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778167/
https://www.ncbi.nlm.nih.gov/pubmed/35056893
http://dx.doi.org/10.3390/molecules27020575
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author Chien, Mei-Yin
Yang, Chih-Min
Chen, Chao-Hsiang
author_facet Chien, Mei-Yin
Yang, Chih-Min
Chen, Chao-Hsiang
author_sort Chien, Mei-Yin
collection PubMed
description The aim of this study was to investigate the effects of the physical properties (diameter size, powder particle size, composition of bark- and wood-tissue, and turnover rate) and processing methods on the content of active ingredients in Astragali radix (AR), a popular Chinese herbal medicine. The astragaloside IV and flavonoid contents increased with decreasing diameter size. Bark-tissue had significantly higher astragaloside IV and formononetin content than that in the wood-tissue. As a higher proportion of bark-tissue is associated with decreasing diameter, a strong correlation was also shown between bark- to wood-tissue ratio and active ingredients’ content. Furthermore, an increase in astragaloside IV content was observed in thin powder as compared to coarse powder ground from the whole root. However, this association between active ingredients’ content and powder particle size was abolished when isolating bark- and wood-tissue individually. Moreover, AR stir-frying with refined honey, a typical processing method of AR, increased formononetin content. The turnover rate of active constituents upon decoction ranged from 61.9–81.4%. Assessing the active constituent contents using its physical properties and processing methods allows for a more comprehensive understanding of optimizing and strengthening the therapeutic potentials of AR used in food and herbal supplements.
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spelling pubmed-87781672022-01-22 Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix Chien, Mei-Yin Yang, Chih-Min Chen, Chao-Hsiang Molecules Article The aim of this study was to investigate the effects of the physical properties (diameter size, powder particle size, composition of bark- and wood-tissue, and turnover rate) and processing methods on the content of active ingredients in Astragali radix (AR), a popular Chinese herbal medicine. The astragaloside IV and flavonoid contents increased with decreasing diameter size. Bark-tissue had significantly higher astragaloside IV and formononetin content than that in the wood-tissue. As a higher proportion of bark-tissue is associated with decreasing diameter, a strong correlation was also shown between bark- to wood-tissue ratio and active ingredients’ content. Furthermore, an increase in astragaloside IV content was observed in thin powder as compared to coarse powder ground from the whole root. However, this association between active ingredients’ content and powder particle size was abolished when isolating bark- and wood-tissue individually. Moreover, AR stir-frying with refined honey, a typical processing method of AR, increased formononetin content. The turnover rate of active constituents upon decoction ranged from 61.9–81.4%. Assessing the active constituent contents using its physical properties and processing methods allows for a more comprehensive understanding of optimizing and strengthening the therapeutic potentials of AR used in food and herbal supplements. MDPI 2022-01-17 /pmc/articles/PMC8778167/ /pubmed/35056893 http://dx.doi.org/10.3390/molecules27020575 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chien, Mei-Yin
Yang, Chih-Min
Chen, Chao-Hsiang
Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title_full Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title_fullStr Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title_full_unstemmed Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title_short Effects of Physical Properties and Processing Methods on Astragaloside IV and Flavonoids Content in Astragali radix
title_sort effects of physical properties and processing methods on astragaloside iv and flavonoids content in astragali radix
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778167/
https://www.ncbi.nlm.nih.gov/pubmed/35056893
http://dx.doi.org/10.3390/molecules27020575
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