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Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy

Aims: Non-ischaemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular (LV) chamber enlargement and systolic dysfunction in the absence of coronary artery disease. Left ventricular reverse remodelling (LVRR) is the ability of a dilated ventricle to restore its normal size, shape and...

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Autores principales: Díez-López, Carles, Salazar-Mendiguchía, Joel, García-Romero, Elena, Fuentes, Lara, Lupón, Josep, Bayés-Genis, Antoni, Manito, Nicolás, de Antonio, Marta, Moliner, Pedro, Zamora, Elisabet, Catalá-Ruiz, Pablo, Caínzos-Achirica, Miguel, Comín-Colet, Josep, González-Costello, José
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778173/
https://www.ncbi.nlm.nih.gov/pubmed/35050230
http://dx.doi.org/10.3390/jcdd9010020
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author Díez-López, Carles
Salazar-Mendiguchía, Joel
García-Romero, Elena
Fuentes, Lara
Lupón, Josep
Bayés-Genis, Antoni
Manito, Nicolás
de Antonio, Marta
Moliner, Pedro
Zamora, Elisabet
Catalá-Ruiz, Pablo
Caínzos-Achirica, Miguel
Comín-Colet, Josep
González-Costello, José
author_facet Díez-López, Carles
Salazar-Mendiguchía, Joel
García-Romero, Elena
Fuentes, Lara
Lupón, Josep
Bayés-Genis, Antoni
Manito, Nicolás
de Antonio, Marta
Moliner, Pedro
Zamora, Elisabet
Catalá-Ruiz, Pablo
Caínzos-Achirica, Miguel
Comín-Colet, Josep
González-Costello, José
author_sort Díez-López, Carles
collection PubMed
description Aims: Non-ischaemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular (LV) chamber enlargement and systolic dysfunction in the absence of coronary artery disease. Left ventricular reverse remodelling (LVRR) is the ability of a dilated ventricle to restore its normal size, shape and function. We sought to determine the frequency, clinical predictors and prognostic implications of LVRR, in a cohort of heart failure (HF) patients with NIDCM. Methods: We conducted a multicentre observational, retrospective cohort study of patients with NIDCM, with prospective serial echocardiography evaluations. LVRR was defined as an increase of ≥15% in left ventricular ejection fraction (LVEF) or as a LVEF increase ≥ 10% plus reduction of LV end-systolic diameter index ≥ 20%. We used multivariable logistic regression analyses to identify the baseline clinical predictors of LVRR and evaluate the prognostic impact of LVRR. Results: LVRR was achieved in 42.5% of 527 patients with NIDCM during the first year of follow-up (median LVEF 49%, median change +22%), Alcoholic aetiology, HF duration, baseline LVEF and the absence of LBBB (plus NT-proBNP levels when in the model), were the strongest predictors of LVRR. During a median follow-up of 47 months, 134 patients died (25.4%) and 7 patients (1.3%) received a heart transplant. Patients with LVRR presented better outcomes, regardless of other clinical conditions. Conclusions: In patients with NIDCM, LVRR was frequent and was associated with improved prognosis. Major clinical predictors of LVRR were alcoholic cardiomyopathy, absence of LBBB, shorter HF duration, and lower baseline LVEF and NT-proBNP levels. Our study advocates for clinical phenotyping of non-ischaemic dilated cardiomyopathy and intense gold-standard treatment optimization of patients according to current guidelines and recommendations in specialized HF units.
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spelling pubmed-87781732022-01-22 Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy Díez-López, Carles Salazar-Mendiguchía, Joel García-Romero, Elena Fuentes, Lara Lupón, Josep Bayés-Genis, Antoni Manito, Nicolás de Antonio, Marta Moliner, Pedro Zamora, Elisabet Catalá-Ruiz, Pablo Caínzos-Achirica, Miguel Comín-Colet, Josep González-Costello, José J Cardiovasc Dev Dis Article Aims: Non-ischaemic dilated cardiomyopathy (NIDCM) is characterized by left ventricular (LV) chamber enlargement and systolic dysfunction in the absence of coronary artery disease. Left ventricular reverse remodelling (LVRR) is the ability of a dilated ventricle to restore its normal size, shape and function. We sought to determine the frequency, clinical predictors and prognostic implications of LVRR, in a cohort of heart failure (HF) patients with NIDCM. Methods: We conducted a multicentre observational, retrospective cohort study of patients with NIDCM, with prospective serial echocardiography evaluations. LVRR was defined as an increase of ≥15% in left ventricular ejection fraction (LVEF) or as a LVEF increase ≥ 10% plus reduction of LV end-systolic diameter index ≥ 20%. We used multivariable logistic regression analyses to identify the baseline clinical predictors of LVRR and evaluate the prognostic impact of LVRR. Results: LVRR was achieved in 42.5% of 527 patients with NIDCM during the first year of follow-up (median LVEF 49%, median change +22%), Alcoholic aetiology, HF duration, baseline LVEF and the absence of LBBB (plus NT-proBNP levels when in the model), were the strongest predictors of LVRR. During a median follow-up of 47 months, 134 patients died (25.4%) and 7 patients (1.3%) received a heart transplant. Patients with LVRR presented better outcomes, regardless of other clinical conditions. Conclusions: In patients with NIDCM, LVRR was frequent and was associated with improved prognosis. Major clinical predictors of LVRR were alcoholic cardiomyopathy, absence of LBBB, shorter HF duration, and lower baseline LVEF and NT-proBNP levels. Our study advocates for clinical phenotyping of non-ischaemic dilated cardiomyopathy and intense gold-standard treatment optimization of patients according to current guidelines and recommendations in specialized HF units. MDPI 2022-01-11 /pmc/articles/PMC8778173/ /pubmed/35050230 http://dx.doi.org/10.3390/jcdd9010020 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Díez-López, Carles
Salazar-Mendiguchía, Joel
García-Romero, Elena
Fuentes, Lara
Lupón, Josep
Bayés-Genis, Antoni
Manito, Nicolás
de Antonio, Marta
Moliner, Pedro
Zamora, Elisabet
Catalá-Ruiz, Pablo
Caínzos-Achirica, Miguel
Comín-Colet, Josep
González-Costello, José
Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title_full Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title_fullStr Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title_full_unstemmed Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title_short Clinical Determinants and Prognosis of Left Ventricular Reverse Remodelling in Non-Ischemic Dilated Cardiomyopathy
title_sort clinical determinants and prognosis of left ventricular reverse remodelling in non-ischemic dilated cardiomyopathy
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778173/
https://www.ncbi.nlm.nih.gov/pubmed/35050230
http://dx.doi.org/10.3390/jcdd9010020
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