Cargando…

Safety, Stability, and Therapeutic Efficacy of Long-Circulating TQ-Incorporated Liposomes: Implication in the Treatment of Lung Cancer

Thymoquinone (TQ), which is one of the main bioactive constituents of Nigella sativa seeds, has demonstrated its potential against various cancer models. The poor solubility of TQ in aqueous solution limits its uses in clinical application. The present study aimed to develop a novel formulation of T...

Descripción completa

Detalles Bibliográficos
Autores principales:	Khan, Arif, Alsahli, Mohammed A., Aljasir, Mohammad A., Maswadeh, Hamzah, Mobark, Mugahid A., Azam, Faizul, Allemailem, Khaled S., Alrumaihi, Faris, Alhumaydhi, Fahad A., Alwashmi, Ameen S. S., Almatroudi, Ahmed A., Alsugoor, Mahdi H., Khan, Masood A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778344/ https://www.ncbi.nlm.nih.gov/pubmed/35057049 http://dx.doi.org/10.3390/pharmaceutics14010153

Ejemplares similares

Experimental and Theoretical Insights on Chemopreventive Effect of the Liposomal Thymoquinone Against Benzo[a]pyrene-Induced Lung Cancer in Swiss Albino Mice
por: Khan, Arif, et al.
Publicado: (2022)

Diallyl Sulfide-Mediated Modulation of the Fatty Acid Synthase (FASN) Leads to Cancer Cell Death in BaP-Induced Lung Carcinogenesis in Swiss Mice
por: Khan, Arif, et al.
Publicado: (2020)

Liposomal Ellagic Acid Alleviates Cyclophosphamide-Induced Toxicity and Eliminates the Systemic Cryptococcus neoformans Infection in Leukopenic Mice
por: Khan, Masood Alam, et al.
Publicado: (2021)

The Effect of Liposomal Diallyl Disulfide and Oxaliplatin on Proliferation of Colorectal Cancer Cells: In Vitro and In Silico Analysis
por: Alrumaihi, Faris, et al.
Publicado: (2022)

Coadministration of Ginger Extract and Fluconazole Shows a Synergistic Effect in the Treatment of Drug-Resistant Vulvovaginal Candidiasis
por: Khan, Arif, et al.
Publicado: (2021)

Garlic Extract Alleviates Trastuzumab-Induced Hepatotoxicity in Rats Through Its Antioxidant, Anti-Inflammatory, and Antihyperlipidemic Effects
por: Mousa, Ayman M, et al.
Publicado: (2021)

Cytoprotective Antioxidant, Anti-Inflammatory, and Antifibrotic Impact of Celery Seed Oil and Manuka Honey Against Cyclophosphamide-Induced Cystitis in Rabbits
por: Mousa, Ayman M., et al.
Publicado: (2022)

Lipid-Based Nanoparticle Formulation of Diallyl Trisulfide Chemosensitizes the Growth Inhibitory Activity of Doxorubicin in Colorectal Cancer Model: A Novel In Vitro, In Vivo and In Silico Analysis
por: Alrumaihi, Faris, et al.
Publicado: (2022)

Safety and Therapeutic Efficacy of Thymoquinone-Loaded Liposomes against Drug-Sensitive and Drug-Resistant Acinetobacter baumannii
por: Allemailem, Khaled S., et al.
Publicado: (2021)

Encapsulation of MERS antigen into α-GalCer-bearing-liposomes elicits stronger effector and memory immune responses in immunocompetent and leukopenic mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Could Mesna and Celery Seed Cotherapy Modulate Oxidative Stress and Inflammation of the Urinary Bladder Induced by Ifosfamide in Rabbits?
por: Mousa, Ayman M, et al.
Publicado: (2021)

Methanolic Fenugreek Seed Extract Induces p53-Dependent Mitotic Catastrophe in Breast Cancer Cells, Leading to Apoptosis
por: Alrumaihi, Faris A, et al.
Publicado: (2021)

Safety and Prophylactic Efficacy of Liposome-Based Vaccine against the Drug-Resistant Acinetobacter baumannii in Mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Potential of Methylglyoxal-Conjugated Chitosan Nanoparticles in Treatment of Fluconazole-Resistant Candida albicans Infection in a Murine Model
por: Khan, Shaheer Hasan, et al.
Publicado: (2020)

Glycosphingolipids (GSLs) from Sphingomonas paucimobilis Increase the Efficacy of Liposome-Based Nanovaccine against Acinetobacter baumannii-Associated Pneumonia in Immunocompetent and Immunocompromised Mice
por: Khan, Masood Alam, et al.
Publicado: (2022)

Therapeutic Effect of Bilsaan, Sambucus nigra Stem Exudate, on the OVA-Induced Allergic Asthma in Mice
por: Alrumaihi, Faris, et al.
Publicado: (2020)

Antimicrobial, Immunomodulatory and Anti-Inflammatory Potential of Liposomal Thymoquinone: Implications in the Treatment of Bacterial Pneumonia in Immunocompromised Mice
por: Allemailem, Khaled S., et al.
Publicado: (2021)

Current updates of CRISPR/Cas9‐mediated genome editing and targeting within tumor cells: an innovative strategy of cancer management
por: Allemailem, Khaled S., et al.
Publicado: (2022)

Etoposide Incorporated into Camel Milk Phospholipids Liposomes Shows Increased Activity against Fibrosarcoma in a Mouse Model
por: Maswadeh, Hamzah M., et al.
Publicado: (2015)

Curcumin, an Active Constituent of Turmeric Spice: Implication in the Prevention of Lung Injury Induced by Benzo(a) Pyrene (BaP) in Rats
por: Almatroodi, Saleh A., et al.
Publicado: (2020)

Coadministration of doxorubicin and etoposide loaded in camel milk phospholipids liposomes showed increased antitumor activity in a murine model
por: Maswadeh, Hamzah M, et al.
Publicado: (2015)

Innovative Strategies of Reprogramming Immune System Cells by Targeting CRISPR/Cas9-Based Genome-Editing Tools: A New Era of Cancer Management
por: Allemailem, Khaled S, et al.
Publicado: (2023)

Potential Therapeutic Targets of Epigallocatechin Gallate (EGCG), the Most Abundant Catechin in Green Tea, and Its Role in the Therapy of Various Types of Cancer
por: Almatroodi, Saleh A., et al.
Publicado: (2020)

Prevalence and associated factors of respiratory allergies in the Kingdom of Saudi Arabia: A cross-sectional investigation, September–December 2020
por: Almatroudi, Ahmad, et al.
Publicado: (2021)

An In-Silico Investigation to Design a Multi-Epitopes Vaccine against Multi-Drug Resistant Hafnia alvei
por: Alshabrmi, Fahad M., et al.
Publicado: (2022)

6-Gingerol, a Major Ingredient of Ginger Attenuates Diethylnitrosamine-Induced Liver Injury in Rats through the Modulation of Oxidative Stress and Anti-Inflammatory Activity
por: Alsahli, Mohammed A., et al.
Publicado: (2021)

Novel Approaches of Dysregulating Lysosome Functions in Cancer Cells by Specific Drugs and Its Nanoformulations: A Smart Approach of Modern Therapeutics
por: Allemailem, Khaled S, et al.
Publicado: (2021)

Myricetin: A Significant Emphasis on Its Anticancer Potential via the Modulation of Inflammation and Signal Transduction Pathways
por: Rahmani, Arshad Husain, et al.
Publicado: (2023)

Effects and Mechanisms of Kaempferol in the Management of Cancers through Modulation of Inflammation and Signal Transduction Pathways
por: Almatroudi, Ahmad, et al.
Publicado: (2023)

Therapeutic potential of thymoquinone liposomes against the systemic infection of Candida albicans in diabetic mice
por: Khan, Masood A., et al.
Publicado: (2018)

Population pharmacokinetic analysis of TQ-B3203 following intravenous administration of TQ-B3203 liposome injection in Chinese patients with advanced solid tumors
por: Li, Xiaoqing, et al.
Publicado: (2023)

Fatty Acid Synthase (FASN) siRNA-Encapsulated-Her-2 Targeted Fab’-Immunoliposomes for Gene Silencing in Breast Cancer Cells
por: Khan, Arif, et al.
Publicado: (2020)

Endoplasmic Reticulum Stress Provocation by Different Nanoparticles: An Innovative Approach to Manage the Cancer and Other Common Diseases
por: Khan, Amjad Ali, et al.
Publicado: (2020)

Hand Hygiene Knowledge and Perception among the Healthcare Workers during the COVID-19 Pandemic in Qassim, Saudi Arabia: A Cross-Sectional Survey
por: Abalkhail, Adil, et al.
Publicado: (2021)

The Anti-Inflammatory Effect of a γ-Lactone Isolated from Ostrich Oil of Struthio camelus (Ratite) and Its Formulated Nano-Emulsion in Formalin-Induced Paw Edema
por: Eltom, Salah E. M., et al.
Publicado: (2021)

Recent Advances in Genome-Editing Technology with CRISPR/Cas9 Variants and Stimuli-Responsive Targeting Approaches within Tumor Cells: A Future Perspective of Cancer Management
por: Allemailem, Khaled S., et al.
Publicado: (2023)

Design of a Multi-Epitopes Based Chimeric Vaccine against Enterobacter cloacae Using Pan-Genome and Reverse Vaccinology Approaches
por: Al-Megrin, Wafa Abdullah I., et al.
Publicado: (2022)

Epigallocatechin-3-Gallate (EGCG), an Active Compound of Green Tea Attenuates Acute Lung Injury Regulating Macrophage Polarization and Krüpple-Like-Factor 4 (KLF4) Expression
por: Almatroodi, Saleh A., et al.
Publicado: (2020)

Role of Cytokines and Chemokines in NSCLC Immune Navigation and Proliferation
por: Ramachandran, Sowmya, et al.
Publicado: (2021)

Rare top quark production in ATLAS ($t\bar{t}t\bar{t}$, $tqZ$, $tq\gamma$)
por: Sabatini, Paolo
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_ds8cbihkh7ausocpf8gv398tfe