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Current Understanding of the Pathogenesis of Porcine Circovirus 3
Circoviruses are closed, circular, single-stranded DNA viruses belonging to the family Circoviridae and the genus Circovirus. To date, at least four porcine circoviruses (PCVs) have been recognized, including PCV1 to PCV4, respectively. Similar to PCV2 pathogenesis, PCV3 has been reported worldwide...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778431/ https://www.ncbi.nlm.nih.gov/pubmed/35056012 http://dx.doi.org/10.3390/pathogens11010064 |
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author | Sirisereewan, Chaitawat Thanawongnuwech, Roongroje Kedkovid, Roongtham |
author_facet | Sirisereewan, Chaitawat Thanawongnuwech, Roongroje Kedkovid, Roongtham |
author_sort | Sirisereewan, Chaitawat |
collection | PubMed |
description | Circoviruses are closed, circular, single-stranded DNA viruses belonging to the family Circoviridae and the genus Circovirus. To date, at least four porcine circoviruses (PCVs) have been recognized, including PCV1 to PCV4, respectively. Similar to PCV2 pathogenesis, PCV3 has been reported worldwide with myriad clinical and pathological presentations such as reproductive disorders, respiratory diseases, diarrhea etc. Current understanding of PCV3 pathogenesis is very limited since the majority of studies were mostly field observations. Interpretation of the results from such studies is not always simple. Various confounding factors affect the clinical appearance and pathological changes of the infected pigs. Recently, several experimental PCV3 infection studies have been reported, providing a better understanding of its pathogenesis. In this review, we focused on novel findings regarding PCV3 pathogenesis from both field observation and experimental infection studies. Possible factors involved in the conflicting results among the experimental infection studies are also discussed. This review article provides important insight into the current knowledge on PCV3 pathogenesis which would aid in prioritizing research in order to fill the knowledge gaps. |
format | Online Article Text |
id | pubmed-8778431 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87784312022-01-22 Current Understanding of the Pathogenesis of Porcine Circovirus 3 Sirisereewan, Chaitawat Thanawongnuwech, Roongroje Kedkovid, Roongtham Pathogens Review Circoviruses are closed, circular, single-stranded DNA viruses belonging to the family Circoviridae and the genus Circovirus. To date, at least four porcine circoviruses (PCVs) have been recognized, including PCV1 to PCV4, respectively. Similar to PCV2 pathogenesis, PCV3 has been reported worldwide with myriad clinical and pathological presentations such as reproductive disorders, respiratory diseases, diarrhea etc. Current understanding of PCV3 pathogenesis is very limited since the majority of studies were mostly field observations. Interpretation of the results from such studies is not always simple. Various confounding factors affect the clinical appearance and pathological changes of the infected pigs. Recently, several experimental PCV3 infection studies have been reported, providing a better understanding of its pathogenesis. In this review, we focused on novel findings regarding PCV3 pathogenesis from both field observation and experimental infection studies. Possible factors involved in the conflicting results among the experimental infection studies are also discussed. This review article provides important insight into the current knowledge on PCV3 pathogenesis which would aid in prioritizing research in order to fill the knowledge gaps. MDPI 2022-01-04 /pmc/articles/PMC8778431/ /pubmed/35056012 http://dx.doi.org/10.3390/pathogens11010064 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Sirisereewan, Chaitawat Thanawongnuwech, Roongroje Kedkovid, Roongtham Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title | Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title_full | Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title_fullStr | Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title_full_unstemmed | Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title_short | Current Understanding of the Pathogenesis of Porcine Circovirus 3 |
title_sort | current understanding of the pathogenesis of porcine circovirus 3 |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778431/ https://www.ncbi.nlm.nih.gov/pubmed/35056012 http://dx.doi.org/10.3390/pathogens11010064 |
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