A High-Methionine Diet for One-Week Induces a High Accumulation of Methionine in the Cerebrospinal Fluid and Confers Bipolar Disorder-like Behavior in Mice

Methionine (Met) is considered the most toxic amino acid in mammals. Here, we investigated biochemical and behavioral impacts of ad libitum one-week feeding of high-Met diets on mice. Adult male mice were fed the standard rodent diet that contained 0.44% Met (1×) or a diet containing 16 graded Met d...

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Detalles Bibliográficos
Autores principales: Ishii, Isao, Kamata, Shotaro, Ito, Saki, Shimonaga, Aya, Koizumi, Maika, Tsushima, Maiko, Miura, Asumi, Nagata, Tomoko, Tosaka, Yuka, Ohtani, Haruka, Kamichatani, Waka, Akahoshi, Noriyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778486/
https://www.ncbi.nlm.nih.gov/pubmed/35055113
http://dx.doi.org/10.3390/ijms23020928

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