Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines

It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been reported. Based on these findings, recently released “Japanese Surviving Sepsis Campaign guidel...

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Autores principales: Iba, Toshiaki, Nishida, Osamu, Levy, Jerrold H., Levi, Marcel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Letter to the Editor
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778504/
https://www.ncbi.nlm.nih.gov/pubmed/35063025
http://dx.doi.org/10.1186/s40560-022-00596-6
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author Iba, Toshiaki
Nishida, Osamu
Levy, Jerrold H.
Levi, Marcel
author_facet Iba, Toshiaki
Nishida, Osamu
Levy, Jerrold H.
Levi, Marcel
author_sort Iba, Toshiaki
collection PubMed
description It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been reported. Based on these findings, recently released “Japanese Surviving Sepsis Campaign guidelines 2020” recommend the diagnosis of DIC and the application of anticoagulants for sepsis-associated DIC. Meanwhile, the updated “International Guidelines for the Management of Sepsis and Septic Shock 2021” did not mention coagulation abnormalities or DIC. Because management strategies continue to evolve to provide improved outcomes in sepsis, the role of adjunctive anticoagulant treatment should be included in subsequent international guidelines.
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spelling pubmed-87785042022-01-21 Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines Iba, Toshiaki Nishida, Osamu Levy, Jerrold H. Levi, Marcel J Intensive Care Letter to the Editor It is generally accepted that a coagulation/fibrinolysis disorder is involved in the pathogenesis of sepsis, and the association of disseminated intravascular coagulation (DIC) and poor outcomes have been reported. Based on these findings, recently released “Japanese Surviving Sepsis Campaign guidelines 2020” recommend the diagnosis of DIC and the application of anticoagulants for sepsis-associated DIC. Meanwhile, the updated “International Guidelines for the Management of Sepsis and Septic Shock 2021” did not mention coagulation abnormalities or DIC. Because management strategies continue to evolve to provide improved outcomes in sepsis, the role of adjunctive anticoagulant treatment should be included in subsequent international guidelines. BioMed Central 2022-01-21 /pmc/articles/PMC8778504/ /pubmed/35063025 http://dx.doi.org/10.1186/s40560-022-00596-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Letter to the Editor
Iba, Toshiaki
Nishida, Osamu
Levy, Jerrold H.
Levi, Marcel
Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title_full Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title_fullStr Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title_full_unstemmed Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title_short Nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
title_sort nevertheless, the importance of coagulation abnormalities should be emphasized in international sepsis guidelines
topic Letter to the Editor
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778504/
https://www.ncbi.nlm.nih.gov/pubmed/35063025
http://dx.doi.org/10.1186/s40560-022-00596-6
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