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Early Preeclampsia Effect on Preterm Newborns Outcome
Background: An early form of preeclampsia is rare. Abnormal placentation, placental perfusion disorders, and inflammatory cytokine release will have an effect on the fetus and newborn. Material and methods: The study group consisted of preterm newborns whose mothers had a history of preeclampsia and...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778539/ https://www.ncbi.nlm.nih.gov/pubmed/35054146 http://dx.doi.org/10.3390/jcm11020452 |
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author | Matyas, Melinda Hasmasanu, Monica Silaghi, Ciprian N. Samasca, Gabriel Lupan, Iulia Orsolya, Kovacs Zaharie, Gabriela |
author_facet | Matyas, Melinda Hasmasanu, Monica Silaghi, Ciprian N. Samasca, Gabriel Lupan, Iulia Orsolya, Kovacs Zaharie, Gabriela |
author_sort | Matyas, Melinda |
collection | PubMed |
description | Background: An early form of preeclampsia is rare. Abnormal placentation, placental perfusion disorders, and inflammatory cytokine release will have an effect on the fetus and newborn. Material and methods: The study group consisted of preterm newborns whose mothers had a history of preeclampsia and a gestational age of between 30 weeks and 34 weeks + 6 days. The control group consists of neonates matched for gestational age with the case group, whose mothers had normal blood pressure. The incidence and severity of respiratory distress syndrome (RDS), intraventricular hemorrhage, hypoglycemia, pH gas changes, and hematological parameters were analyzed in the two groups. Results: The study group of preterm neonates had a lower birth weight than the control group (p < 0.001). Most of the deliveries in the group of newborns exposed to preeclampsia were performed by cesarean section. Severe forms of RDS were two times more frequent in the group of newborns exposed to preeclampsia compared to those in the control group. Even though we expected to see a lower incidence, owing to the high number of deliveries by cesarean section, we still observed a higher rate of intraventricular hemorrhage in the preeclampsia group (16 cases in the study group vs. 7 in the control, p = 0.085). Neutropenia and thrombocytopenia were more frequent in preterm newborns exposed to preeclampsia. Conclusions: The study shows that early preeclampsia increases the risk of complications in preterm neonates. RDS was more frequent in the exposed group than in the control group. The severity of preeclampsia correlates with hematological changes. |
format | Online Article Text |
id | pubmed-8778539 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87785392022-01-22 Early Preeclampsia Effect on Preterm Newborns Outcome Matyas, Melinda Hasmasanu, Monica Silaghi, Ciprian N. Samasca, Gabriel Lupan, Iulia Orsolya, Kovacs Zaharie, Gabriela J Clin Med Article Background: An early form of preeclampsia is rare. Abnormal placentation, placental perfusion disorders, and inflammatory cytokine release will have an effect on the fetus and newborn. Material and methods: The study group consisted of preterm newborns whose mothers had a history of preeclampsia and a gestational age of between 30 weeks and 34 weeks + 6 days. The control group consists of neonates matched for gestational age with the case group, whose mothers had normal blood pressure. The incidence and severity of respiratory distress syndrome (RDS), intraventricular hemorrhage, hypoglycemia, pH gas changes, and hematological parameters were analyzed in the two groups. Results: The study group of preterm neonates had a lower birth weight than the control group (p < 0.001). Most of the deliveries in the group of newborns exposed to preeclampsia were performed by cesarean section. Severe forms of RDS were two times more frequent in the group of newborns exposed to preeclampsia compared to those in the control group. Even though we expected to see a lower incidence, owing to the high number of deliveries by cesarean section, we still observed a higher rate of intraventricular hemorrhage in the preeclampsia group (16 cases in the study group vs. 7 in the control, p = 0.085). Neutropenia and thrombocytopenia were more frequent in preterm newborns exposed to preeclampsia. Conclusions: The study shows that early preeclampsia increases the risk of complications in preterm neonates. RDS was more frequent in the exposed group than in the control group. The severity of preeclampsia correlates with hematological changes. MDPI 2022-01-17 /pmc/articles/PMC8778539/ /pubmed/35054146 http://dx.doi.org/10.3390/jcm11020452 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Matyas, Melinda Hasmasanu, Monica Silaghi, Ciprian N. Samasca, Gabriel Lupan, Iulia Orsolya, Kovacs Zaharie, Gabriela Early Preeclampsia Effect on Preterm Newborns Outcome |
title | Early Preeclampsia Effect on Preterm Newborns Outcome |
title_full | Early Preeclampsia Effect on Preterm Newborns Outcome |
title_fullStr | Early Preeclampsia Effect on Preterm Newborns Outcome |
title_full_unstemmed | Early Preeclampsia Effect on Preterm Newborns Outcome |
title_short | Early Preeclampsia Effect on Preterm Newborns Outcome |
title_sort | early preeclampsia effect on preterm newborns outcome |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778539/ https://www.ncbi.nlm.nih.gov/pubmed/35054146 http://dx.doi.org/10.3390/jcm11020452 |
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