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The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure

Premature ovarian failure (POF) refers to ovarian dysfunction in women under 40 years old. It is characterized by low estrogen, high gonadotropin, amenorrhea, and infertility, which seriously affect physical and mental health of women. The pathogenic factors of POF include iatrogenic factors, autoim...

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Autores principales: Chen, Haoran, Liu, Chi, Zhu, Shaomi, Li, Shaowei, Zhang, Qinxiu, Song, Linjiang, Liang, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Bentham Science Publishers 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778633/
https://www.ncbi.nlm.nih.gov/pubmed/32888266
http://dx.doi.org/10.2174/1566524020666200905113907
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author Chen, Haoran
Liu, Chi
Zhu, Shaomi
Li, Shaowei
Zhang, Qinxiu
Song, Linjiang
Liang, Xin
author_facet Chen, Haoran
Liu, Chi
Zhu, Shaomi
Li, Shaowei
Zhang, Qinxiu
Song, Linjiang
Liang, Xin
author_sort Chen, Haoran
collection PubMed
description Premature ovarian failure (POF) refers to ovarian dysfunction in women under 40 years old. It is characterized by low estrogen, high gonadotropin, amenorrhea, and infertility, which seriously affect physical and mental health of women. The pathogenic factors of POF include iatrogenic factors, autoimmune factors, genetic factors, oxidative stress, infection, thyroid dysfunction, and adrenal diseases. Chemotherapy is a common cause of POF and is gaining increasing attention. With the development of modern medicine and advances in understanding cancer, women’s cancer survival rates have been significantly increased. Currently, the main treatment options for POF are hormone supplement and in vitro activation (IVA), but there is still no specific treatment for POF. Stem cells, known as undifferentiated cells of multicellular organisms, exhibit characteristics of self-renewal, directional differentiation into different cells, and low immunogenicity. Thus, they have potential in regenerative medicine and provide a promising direction for POF treatment. In this review, we summarize the latest research progress of various stem cells in chemotherapy-induced POF models to provide a theoretical basis for further research and treatment.
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spelling pubmed-87786332022-02-07 The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure Chen, Haoran Liu, Chi Zhu, Shaomi Li, Shaowei Zhang, Qinxiu Song, Linjiang Liang, Xin Curr Mol Med Article Premature ovarian failure (POF) refers to ovarian dysfunction in women under 40 years old. It is characterized by low estrogen, high gonadotropin, amenorrhea, and infertility, which seriously affect physical and mental health of women. The pathogenic factors of POF include iatrogenic factors, autoimmune factors, genetic factors, oxidative stress, infection, thyroid dysfunction, and adrenal diseases. Chemotherapy is a common cause of POF and is gaining increasing attention. With the development of modern medicine and advances in understanding cancer, women’s cancer survival rates have been significantly increased. Currently, the main treatment options for POF are hormone supplement and in vitro activation (IVA), but there is still no specific treatment for POF. Stem cells, known as undifferentiated cells of multicellular organisms, exhibit characteristics of self-renewal, directional differentiation into different cells, and low immunogenicity. Thus, they have potential in regenerative medicine and provide a promising direction for POF treatment. In this review, we summarize the latest research progress of various stem cells in chemotherapy-induced POF models to provide a theoretical basis for further research and treatment. Bentham Science Publishers 2021-08-05 2021-08-05 /pmc/articles/PMC8778633/ /pubmed/32888266 http://dx.doi.org/10.2174/1566524020666200905113907 Text en © 2021 Bentham Science Publishers https://creativecommons.org/licenses/by-nc/4.0/ This is an open access article licensed under the terms of the Creative Commons Attribution-Non-Commercial 4.0 International Public License (CC BY-NC 4.0) (https://creativecommons.org/licenses/by-nc/4.0/legalcode), which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
spellingShingle Article
Chen, Haoran
Liu, Chi
Zhu, Shaomi
Li, Shaowei
Zhang, Qinxiu
Song, Linjiang
Liang, Xin
The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title_full The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title_fullStr The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title_full_unstemmed The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title_short The Therapeutic Effect of Stem Cells on Chemotherapy-Induced Premature Ovarian Failure
title_sort therapeutic effect of stem cells on chemotherapy-induced premature ovarian failure
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778633/
https://www.ncbi.nlm.nih.gov/pubmed/32888266
http://dx.doi.org/10.2174/1566524020666200905113907
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