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Polyamine–Oligonucleotide Conjugates: 2′-OMe-Triazole-Linked 1,4,7,10-Tetraazacyclododecane and Intercalating Dyes and Their Effect on the Thermal Stability of DNA Duplexes

Oligonucleotides with the sequences 5′-GTG AU(P)A TGC, 5′-GCA TAU(P) CAC and 5′-GU(P)G ATA U(P)GC, where U(P) is 2′-O-propargyl uridine, were subjected to post-synthetic Cu(I)-catalyzed azide–alkyne cycloaddition to attach 1,4,7,10-tetraazacyclododecane (cyclen) and two well-known DNA intercalating...

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Detalles Bibliográficos
Autores principales:	Tomczyk, Mateusz D., Zalewski, Mariusz, Jørgensen, Per T., Wengel, Jesper, Walczak, Krzysztof
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778778/ https://www.ncbi.nlm.nih.gov/pubmed/35056962 http://dx.doi.org/10.3390/pharmaceutics14010066

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