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The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a mat...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778873/ https://www.ncbi.nlm.nih.gov/pubmed/35056341 http://dx.doi.org/10.3390/medicina58010033 |
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author | Moldovianu, Ana-Maria Crisan, Ana Manuela Varady, Zsofia Coriu, Daniel |
author_facet | Moldovianu, Ana-Maria Crisan, Ana Manuela Varady, Zsofia Coriu, Daniel |
author_sort | Moldovianu, Ana-Maria |
collection | PubMed |
description | Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a matter of intense debate. We report the case of a CLL patient with 17 p deletion treated with ibrutinib as a bridge to allo-HCT. Early relapse after allo-HCT urged the initiation of salvage therapy, including donor lymphocytes infusions, ibrutinib, and venetoclax. We aim to outline and discuss the potential benefits of novel therapies, the current role of allo-HCT in CLL, drug timing and sequencing, and the unmet need to improve the long-term outcome of high-risk CLL patients. |
format | Online Article Text |
id | pubmed-8778873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87788732022-01-22 The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia Moldovianu, Ana-Maria Crisan, Ana Manuela Varady, Zsofia Coriu, Daniel Medicina (Kaunas) Case Report Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a matter of intense debate. We report the case of a CLL patient with 17 p deletion treated with ibrutinib as a bridge to allo-HCT. Early relapse after allo-HCT urged the initiation of salvage therapy, including donor lymphocytes infusions, ibrutinib, and venetoclax. We aim to outline and discuss the potential benefits of novel therapies, the current role of allo-HCT in CLL, drug timing and sequencing, and the unmet need to improve the long-term outcome of high-risk CLL patients. MDPI 2021-12-24 /pmc/articles/PMC8778873/ /pubmed/35056341 http://dx.doi.org/10.3390/medicina58010033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Moldovianu, Ana-Maria Crisan, Ana Manuela Varady, Zsofia Coriu, Daniel The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title | The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title_full | The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title_fullStr | The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title_full_unstemmed | The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title_short | The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia |
title_sort | difficult-to-treat del 17 p patient—a case report in chronic lymphocytic leukemia |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778873/ https://www.ncbi.nlm.nih.gov/pubmed/35056341 http://dx.doi.org/10.3390/medicina58010033 |
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