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The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia

Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a mat...

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Autores principales: Moldovianu, Ana-Maria, Crisan, Ana Manuela, Varady, Zsofia, Coriu, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778873/
https://www.ncbi.nlm.nih.gov/pubmed/35056341
http://dx.doi.org/10.3390/medicina58010033
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author Moldovianu, Ana-Maria
Crisan, Ana Manuela
Varady, Zsofia
Coriu, Daniel
author_facet Moldovianu, Ana-Maria
Crisan, Ana Manuela
Varady, Zsofia
Coriu, Daniel
author_sort Moldovianu, Ana-Maria
collection PubMed
description Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a matter of intense debate. We report the case of a CLL patient with 17 p deletion treated with ibrutinib as a bridge to allo-HCT. Early relapse after allo-HCT urged the initiation of salvage therapy, including donor lymphocytes infusions, ibrutinib, and venetoclax. We aim to outline and discuss the potential benefits of novel therapies, the current role of allo-HCT in CLL, drug timing and sequencing, and the unmet need to improve the long-term outcome of high-risk CLL patients.
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spelling pubmed-87788732022-01-22 The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia Moldovianu, Ana-Maria Crisan, Ana Manuela Varady, Zsofia Coriu, Daniel Medicina (Kaunas) Case Report Chronic lymphocytic leukemia (CLL) treatment strategies have evolved to include mechanism-driven drugs but now raise new questions regarding their optimum timing and sequencing. In high-risk patients, switching from pathway inhibitors to allogeneic stem cell transplantation (allo-HCT) is still a matter of intense debate. We report the case of a CLL patient with 17 p deletion treated with ibrutinib as a bridge to allo-HCT. Early relapse after allo-HCT urged the initiation of salvage therapy, including donor lymphocytes infusions, ibrutinib, and venetoclax. We aim to outline and discuss the potential benefits of novel therapies, the current role of allo-HCT in CLL, drug timing and sequencing, and the unmet need to improve the long-term outcome of high-risk CLL patients. MDPI 2021-12-24 /pmc/articles/PMC8778873/ /pubmed/35056341 http://dx.doi.org/10.3390/medicina58010033 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Moldovianu, Ana-Maria
Crisan, Ana Manuela
Varady, Zsofia
Coriu, Daniel
The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title_full The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title_fullStr The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title_full_unstemmed The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title_short The Difficult-to-Treat del 17 p Patient—A Case Report in Chronic Lymphocytic Leukemia
title_sort difficult-to-treat del 17 p patient—a case report in chronic lymphocytic leukemia
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778873/
https://www.ncbi.nlm.nih.gov/pubmed/35056341
http://dx.doi.org/10.3390/medicina58010033
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