Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production

Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. T...

Descripción completa

Detalles Bibliográficos
Autores principales: Qin, Xiaoya, Huang, Jiguo, Zhou, Dexiong, Zhang, Wenxiu, Zhang, Yanjun, Li, Jun, Yang, Ruiyun, Huang, Xishan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778885/
https://www.ncbi.nlm.nih.gov/pubmed/35049860
http://dx.doi.org/10.3390/md20010005
_version_ 1784637438324375552
author Qin, Xiaoya
Huang, Jiguo
Zhou, Dexiong
Zhang, Wenxiu
Zhang, Yanjun
Li, Jun
Yang, Ruiyun
Huang, Xishan
author_facet Qin, Xiaoya
Huang, Jiguo
Zhou, Dexiong
Zhang, Wenxiu
Zhang, Yanjun
Li, Jun
Yang, Ruiyun
Huang, Xishan
author_sort Qin, Xiaoya
collection PubMed
description Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC(50) values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively.
format Online
Article
Text
id pubmed-8778885
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87788852022-01-22 Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production Qin, Xiaoya Huang, Jiguo Zhou, Dexiong Zhang, Wenxiu Zhang, Yanjun Li, Jun Yang, Ruiyun Huang, Xishan Mar Drugs Article Four undescribed compounds, guhypoxylonols A (1), B (2), C (3), and D (4), were isolated from the mangrove endophytic fungus Aspergillus sp. GXNU-Y45, together with seven previously reported metabolites. The structures of 1–4 were elucidated based on analysis of HRESIMS and NMR spectroscopic data. The absolute configurations of the stereogenic carbons in 1–3 were established through a combination of spectroscopic data and electronic circular dichroism (ECD). Compounds 1–11 were evaluated for their anti-inflammatory activity. Compounds 1, 3, 4, and 6 showed an inhibitory activity against the production of nitric oxide (NO), with the IC(50) values of 14.42 ± 0.11, 18.03 ± 0.14, 16.66 ± 0.21, and 21.05 ± 0.13 μM, respectively. MDPI 2021-12-21 /pmc/articles/PMC8778885/ /pubmed/35049860 http://dx.doi.org/10.3390/md20010005 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Qin, Xiaoya
Huang, Jiguo
Zhou, Dexiong
Zhang, Wenxiu
Zhang, Yanjun
Li, Jun
Yang, Ruiyun
Huang, Xishan
Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title_full Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title_fullStr Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title_full_unstemmed Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title_short Polyketide Derivatives, Guhypoxylonols A–D from a Mangrove Endophytic Fungus Aspergillus sp. GXNU-Y45 That Inhibit Nitric Oxide Production
title_sort polyketide derivatives, guhypoxylonols a–d from a mangrove endophytic fungus aspergillus sp. gxnu-y45 that inhibit nitric oxide production
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778885/
https://www.ncbi.nlm.nih.gov/pubmed/35049860
http://dx.doi.org/10.3390/md20010005
work_keys_str_mv AT qinxiaoya polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT huangjiguo polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT zhoudexiong polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT zhangwenxiu polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT zhangyanjun polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT lijun polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT yangruiyun polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction
AT huangxishan polyketidederivativesguhypoxylonolsadfromamangroveendophyticfungusaspergillusspgxnuy45thatinhibitnitricoxideproduction

Ejemplares similares