Cargando…

The Improved Milk Quality and Enhanced Anti-Inflammatory Effect in Acetylserotonin-O-methyltransferase (ASMT) Overexpressed Goats: An Association with the Elevated Endogenous Melatonin Production

Background: Transgenic animal production is an important means of livestock breeding and can be used to model pharmaceutical applications. Methods: In this study, to explore the biological activity of endogenously produced melatonin, Acetylserotonin-O-methyltransferase (ASMT)-overexpressed melatonin...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wu, Hao, Cui, Xudai, Guan, Shengyu, Li, Guangdong, Yao, Yujun, Wu, Haixin, Zhang, Jinlong, Zhang, Xiaosheng, Yu, Tuan, Li, Yunxiang, Lian, Zhengxing, Zhang, Lu, Liu, Guoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778916/ https://www.ncbi.nlm.nih.gov/pubmed/35056885 http://dx.doi.org/10.3390/molecules27020572

Ejemplares similares

Whole-genome methylation analysis reveals epigenetic variation between wild-type and nontransgenic cloned, ASMT transgenic cloned dairy goats generated by the somatic cell nuclear transfer
por: Wu, Hao, et al.
Publicado: (2022)

A Comparative Genomic and Transcriptomic Survey Provides Novel Insights into N-Acetylserotonin Methyltransferase (ASMT) in Fish
por: Zhang, Kai, et al.
Publicado: (2017)

Melatonin biosynthesis requires N-acetylserotonin methyltransferase activity of caffeic acid O-methyltransferase in rice
por: Byeon, Yeong, et al.
Publicado: (2015)

Responses of Transgenic Melatonin-Enriched Goats on LPS Stimulation and the Proteogenomic Profiles of Their PBMCs
por: Yang, Minghui, et al.
Publicado: (2018)

Effects of SNPs in AANAT and ASMT Genes on Milk and Peripheral Blood Melatonin Concentrations in Holstein Cows (Bos taurus)
por: Yao, Songyang, et al.
Publicado: (2022)

The serotonin-N-acetylserotonin–melatonin pathway as a biomarker for autism spectrum disorders
por: Pagan, C, et al.
Publicado: (2014)

Polymorphisms in the ASMT and ADAMTS1 gene may increase litter size in goats
por: Hu, Wenping, et al.
Publicado: (2020)

Melatonin improves the efficiency of super-ovulation and timed artificial insemination in sheep
por: Song, Yukun, et al.
Publicado: (2019)

Molecular docking studies for the identification of novel melatoninergic inhibitors for acetylserotonin-O-methyltransferase using different docking routines
por: Azam, Syed Sikander, et al.
Publicado: (2013)

Walnut N-Acetylserotonin Methyltransferase Gene Family Genome-Wide Identification and Diverse Functions Characterization During Flower Bud Development
por: Ma, Kai, et al.
Publicado: (2022)

Mutation screening of ASMT, the last enzyme of the melatonin pathway, in a large sample of patients with Intellectual Disability
por: Pagan, Cecile, et al.
Publicado: (2011)

Genome-wide analysis for the melatonin trait associated genes and SNPs in dairy goat (Capra hircus) as the molecular breeding markers
por: Wu, Hao, et al.
Publicado: (2023)

The Effects of Mammary Gland ATIII Overexpression on the General Health of Dairy Goats and Their Anti-Inflammatory Response to LPS Stimulation
por: Yan, Laiqing, et al.
Publicado: (2023)

Domain fusion TLR2-4 enhances the autophagy-dependent clearance of Staphylococcus aureus in the genetic engineering goat
por: Wang, Mengyao, et al.
Publicado: (2022)

Melatonin Promotes the In Vitro Development of Microinjected Pronuclear Mouse Embryos via Its Anti-Oxidative and Anti-Apoptotic Effects
por: Tian, Xiuzhi, et al.
Publicado: (2017)

Genomic Analysis of the ASMT Gene Family in Solanum lycopersicum
por: Liu, Weicheng, et al.
Publicado: (2017)

Glioblastoma: Role of Mitochondria N-acetylserotonin/Melatonin Ratio in Mediating Effects of miR-451 and Aryl Hydrocarbon Receptor and in Coordinating Wider Biochemical Changes
por: Anderson, George, et al.
Publicado: (2019)

Sequencing ASMT Identifies Rare Mutations in Chinese Han Patients with Autism
por: Wang, Lifang, et al.
Publicado: (2013)

ASMT determines gut microbiota and increases neurobehavioral adaptability to exercise in female mice
por: Liu, Weina, et al.
Publicado: (2023)

Beneficial Effects of Melatonin on the In Vitro Maturation of Sheep Oocytes and Its Relation to Melatonin Receptors
por: Tian, Xiuzhi, et al.
Publicado: (2017)

Protective Effect of N-Acetylserotonin against Acute Hepatic Ischemia-Reperfusion Injury in Mice
por: Yu, Shuna, et al.
Publicado: (2013)

Overexpression of Toll-like Receptor 4-linked Mitogen-activated Protein Kinase Signaling Contributes to Internalization of Escherichia coli in Sheep
por: Wang, Sutian, et al.
Publicado: (2018)

Evaluating the effect of TLR4-overexpressing on the transcriptome profile in ovine peripheral blood mononuclear cells
por: Guo, Xiaofei, et al.
Publicado: (2020)

ASMT Regulates Tumor Metastasis Through the Circadian Clock System in Triple-Negative Breast Cancer
por: Xie, FenFen, et al.
Publicado: (2020)

Development and Validation of a 54K Genome-Wide Liquid SNP Chip Panel by Target Sequencing for Dairy Goat
por: Guan, Shengyu, et al.
Publicado: (2023)

RNAi combining Sleeping Beauty transposon system inhibits ex vivo expression of foot-and-mouth disease virus VP1 in transgenic sheep cells
por: Deng, Shoulong, et al.
Publicado: (2017)

Melatonin promotes the growth and development of lambs by increasing growth hormone and testosterone, targeting on apoptosis signaling pathway and intestinal microflora
por: Ma, Wenkui, et al.
Publicado: (2022)

ASMT gene expression correlates with cognitive impairment in patients with recurrent depressive disorder
por: Talarowska, Monika, et al.
Publicado: (2014)

Toll-Like Receptor 4 Promotes NO Synthesis by Upregulating GCHI Expression under Oxidative Stress Conditions in Sheep Monocytes/Macrophages
por: Deng, Shoulong, et al.
Publicado: (2015)

Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
por: Zhang, Rui, et al.
Publicado: (2020)

Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep
por: Deng, Shoulong, et al.
Publicado: (2016)

Melatonin Modulates Lipid Metabolism in Porcine Cumulus–Oocyte Complex via Its Receptors
por: Zhu, Tianqi, et al.
Publicado: (2021)

Effects of melatonin implantation on carcass characteristics, meat quality and tissue levels of melatonin and prolactin in Inner Mongolian cashmere goats
por: Duan, Tao, et al.
Publicado: (2019)

Corrigendum: Melatonin Modulates Lipid Metabolism in Porcine Cumulus–Oocyte Complex via Its Receptors
por: Zhu, Tianqi, et al.
Publicado: (2021)

Analysis of the ASMT Gene Family in Pepper (Capsicum annuum L.): Identification, Phylogeny, and Expression Profiles
por: Pan, Luzhao, et al.
Publicado: (2019)

Melatonin Supplementation during the Late Gestational Stage Enhances Reproductive Performance of Sows by Regulating Fluid Shear Stress and Improving Placental Antioxidant Capacity
por: Wang, Likai, et al.
Publicado: (2023)

Overexpression of MzASMT 1, a Gene From Malus zumi Mats, Enhances Salt Tolerance in Transgenic Tobacco
por: Zhuang, Weibing, et al.
Publicado: (2020)

Overexpression of MsASMT1 Promotes Plant Growth and Decreases Flavonoids Biosynthesis in Transgenic Alfalfa (Medicago sativa L.)
por: Cen, Huifang, et al.
Publicado: (2020)

Overexpression of VvASMT1 from grapevine enhanced salt and osmotic stress tolerance in Nicotiana benthamiana
por: Yu, Yanyan, et al.
Publicado: (2022)

Efficient production of pronuclear embryos in breeding and nonbreeding season for generating transgenic sheep overexpressing TLR4
por: Li, Yan, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_be3reec6is74q4dc92epure200