Cargando…

Kinetics of Blood–Brain Barrier Transport of Monoclonal Antibodies Targeting the Insulin Receptor and the Transferrin Receptor

Biologic drugs are large molecule pharmaceuticals that do not cross the blood–brain barrier (BBB), which is formed by the brain capillary endothelium. Biologics can be re-engineered for BBB transport as IgG fusion proteins, where the IgG domain is a monoclonal antibody (MAb) that targets an endogeno...

Descripción completa

Detalles Bibliográficos
Autor principal:	Pardridge, William M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8778919/ https://www.ncbi.nlm.nih.gov/pubmed/35056060 http://dx.doi.org/10.3390/ph15010003

Ejemplares similares

Mathematical Models of Blood-Brain Barrier Transport of Monoclonal Antibodies Targeting the Transferrin Receptor and the Insulin Receptor
por: Pardridge, William M., et al.
Publicado: (2021)

Blood–Brain Barrier Transport of Transferrin Receptor-Targeted Nanoparticles
por: Thomsen, Maj Schneider, et al.
Publicado: (2022)

Receptor-mediated drug delivery of bispecific therapeutic antibodies through the blood-brain barrier
por: Pardridge, William M.
Publicado: (2023)

Treatment of Parkinson’s disease with biologics that penetrate the blood–brain barrier via receptor-mediated transport
por: Pardridge, William M.
Publicado: (2023)

Pharmacokinetics and Safety in Rhesus Monkeys of a Monoclonal Antibody-GDNF Fusion Protein for Targeted Blood-Brain Barrier Delivery
por: Pardridge, William M., et al.
Publicado: (2009)

Targeting transferrin receptors at the blood-brain barrier improves the uptake of immunoliposomes and subsequent cargo transport into the brain parenchyma
por: Johnsen, Kasper Bendix, et al.
Publicado: (2017)

Insulin Receptor Antibody–Sulfamidase Fusion Protein Penetrates the Primate Blood–Brain Barrier and Reduces Glycosoaminoglycans in Sanfilippo Type A Cells
por: Boado, Ruben J., et al.
Publicado: (2014)

Plasmid DNA gene therapy of the Niemann-Pick C1 mouse with transferrin receptor-targeted Trojan horse liposomes
por: Jiang, Dahai, et al.
Publicado: (2020)

Transferrin Receptor-Targeted Nanocarriers: Overcoming Barriers to Treat Glioblastoma
por: Ramalho, Maria João, et al.
Publicado: (2022)

Treatment of Alzheimer’s Disease and Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2020)

Pathogenic bacteria exploit transferrin receptor transcytosis to penetrate the blood–brain barrier
por: Cheng, Zhihui, et al.
Publicado: (2023)

Acute and Chronic Dosing of a High-Affinity Rat/Mouse Chimeric Transferrin Receptor Antibody in Mice
por: Castellanos, Demi M., et al.
Publicado: (2020)

Advanced Blood–Brain Barrier Drug Delivery
por: Pardridge, William M.
Publicado: (2022)

Blood-Brain Barrier and Delivery of Protein and Gene Therapeutics to Brain
por: Pardridge, William M.
Publicado: (2020)

A Blood-Brain-Barrier-Penetrating Anti-human Transferrin Receptor Antibody Fusion Protein for Neuronopathic Mucopolysaccharidosis II
por: Sonoda, Hiroyuki, et al.
Publicado: (2018)

The Isolated Brain Microvessel: A Versatile Experimental Model of the Blood-Brain Barrier
por: Pardridge, William M.
Publicado: (2020)

Ferroptosis is critical for phthalates driving the blood-testis barrier dysfunction via targeting transferrin receptor
por: Zhao, Yi, et al.
Publicado: (2022)

Transferrin Receptors in Erythropoiesis
por: Richard, Cyrielle, et al.
Publicado: (2020)

Antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles
por: Johnsen, Kasper Bendix, et al.
Publicado: (2018)

The Trojan Horse Liposome Technology for Nonviral Gene Transfer across the Blood-Brain Barrier
por: Boado, Ruben J., et al.
Publicado: (2011)

Therapeutic Bispecific T-Cell Engager Antibody Targeting the Transferrin Receptor
por: Fu, Mingpeng, et al.
Publicado: (2019)

Monoclonal antibodies in neuro-oncology: Getting past the blood-brain barrier
por: Lampson, Lois A
Publicado: (2011)

Intracellular sorting and transcytosis of the rat transferrin receptor antibody OX26 across the blood–brain barrier in vitro is dependent on its binding affinity
por: Haqqani, Arsalan S., et al.
Publicado: (2018)

A Perfused In Vitro Human iPSC-Derived Blood–Brain Barrier Faithfully Mimics Transferrin Receptor-Mediated Transcytosis of Therapeutic Antibodies
por: Burgio, Floriana, et al.
Publicado: (2023)

Standardized Preclinical In Vitro Blood–Brain Barrier Mouse Assay Validates Endocytosis-Dependent Antibody Transcytosis Using Transferrin-Receptor-Mediated Pathways
por: Morrison, Jamie I., et al.
Publicado: (2023)

Questions about horse spleen ferritin crossing the blood brain barrier via mouse transferrin receptor 1
por: Fan, Kelong, et al.
Publicado: (2017)

Brain Cancer Chemotherapy through a Delivery System across the Blood-Brain Barrier into the Brain Based on Receptor-Mediated Transcytosis Using Monoclonal Antibody Conjugates
por: Tashima, Toshihiko
Publicado: (2022)

Bivalent Brain Shuttle Increases Antibody Uptake by Monovalent Binding to the Transferrin Receptor
por: Hultqvist, Greta, et al.
Publicado: (2017)

Exposure of K562 cells to anti-receptor monoclonal antibody OKT9 results in rapid redistribution and enhanced degradation of the transferrin receptor
Publicado: (1986)

Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes
Publicado: (1983)

Transportation of Single-Domain Antibodies through the Blood–Brain Barrier
por: Ruiz-López, Eduardo, et al.
Publicado: (2021)

Transferrin Receptor-Targeted Iduronate-2-sulfatase Penetrates the Blood-Retinal Barrier and Improves Retinopathy in Mucopolysaccharidosis II Mice
por: Imakiire, Atsushi, et al.
Publicado: (2023)

A recycling anti-transferrin receptor-1 monoclonal antibody as an efficient therapy for erythroleukemia through target up-regulation and antibody-dependent cytotoxic effector functions
por: Neiveyans, Madeline, et al.
Publicado: (2019)

Targeting bacterial transferrin and lactoferrin receptors for vaccines
por: Schryvers, Anthony B.
Publicado: (2022)

FLCN regulates transferrin receptor 1 transport and iron homeostasis
por: Wang, Xiaojuan, et al.
Publicado: (2021)

Drug transport in brain via the cerebrospinal fluid
por: Pardridge, William M
Publicado: (2011)

Prospective Design of Anti‐Transferrin Receptor Bispecific Antibodies for Optimal Delivery into the Human Brain
por: Kanodia, JS, et al.
Publicado: (2016)

Rapid endocytosis of the transferrin receptor in the absence of bound transferrin
Publicado: (1985)

Blood-brain barrier transport machineries and targeted therapy of brain diseases
por: Barar, Jaleh, et al.
Publicado: (2016)

Role of transferrin, transferrin receptors, and iron in macrophage listericidal activity
Publicado: (1991)

Cannot write session to /tmp/vufind_sessions/sess_h84u96v2rogvmvh8ci6881246u