Combining Therapeutic Drug Monitoring and Pharmacokinetic Modelling Deconvolutes Physiological and Environmental Sources of Variability in Clozapine Exposure

Background: Clozapine is a key antipsychotic drug for treatment-resistant schizophrenia but exhibits highly variable pharmacokinetics and a propensity for serious adverse effects. Currently, these challenges are addressed using therapeutic drug monitoring (TDM). This study primarily sought to (i) ve...

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Detalles Bibliográficos
Autores principales: Wills, Kenneth H., Behan, Stephen J., Nance, Michael J., Dawson, Jessica L., Polasek, Thomas M., Hopkins, Ashley M., van Dyk, Madelé, Rowland, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779032/
https://www.ncbi.nlm.nih.gov/pubmed/35056943
http://dx.doi.org/10.3390/pharmaceutics14010047

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