Harnessing Synthetic Lethal Interactions for Personalized Medicine

Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill cancer cells but leave normal cells intact. The applicability of translating this con...

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Detalles Bibliográficos
Autor principal: Shieh, Grace S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779047/
https://www.ncbi.nlm.nih.gov/pubmed/35055413
http://dx.doi.org/10.3390/jpm12010098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779047/
https://www.ncbi.nlm.nih.gov/pubmed/35055413
http://dx.doi.org/10.3390/jpm12010098

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