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Harnessing Synthetic Lethal Interactions for Personalized Medicine
Two genes are said to have synthetic lethal (SL) interactions if the simultaneous mutations in a cell lead to lethality, but each individual mutation does not. Targeting SL partners of mutated cancer genes can kill cancer cells but leave normal cells intact. The applicability of translating this con...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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MDPI
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779047/ https://www.ncbi.nlm.nih.gov/pubmed/35055413 http://dx.doi.org/10.3390/jpm12010098 |