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De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor

Coronavirus disease 2019 has developed as a pandemic. Immunization with the introduction of vaccines against COVID-19 seems be the only way to end this pandemic. We report on a case of a kidney donor, who developed minimal change disease (MCD) within 4 days post-vaccination with the SARS-CoV-2 BNT16...

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Autores principales: Marinaki, Smaragdi, Kolovou, Kyriaki, Liapis, George, Skalioti, Chrysanthi, Tsiakas, Stathis, Boletis, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779182/
https://www.ncbi.nlm.nih.gov/pubmed/35056345
http://dx.doi.org/10.3390/medicina58010037
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author Marinaki, Smaragdi
Kolovou, Kyriaki
Liapis, George
Skalioti, Chrysanthi
Tsiakas, Stathis
Boletis, Ioannis
author_facet Marinaki, Smaragdi
Kolovou, Kyriaki
Liapis, George
Skalioti, Chrysanthi
Tsiakas, Stathis
Boletis, Ioannis
author_sort Marinaki, Smaragdi
collection PubMed
description Coronavirus disease 2019 has developed as a pandemic. Immunization with the introduction of vaccines against COVID-19 seems be the only way to end this pandemic. We report on a case of a kidney donor, who developed minimal change disease (MCD) within 4 days post-vaccination with the SARS-CoV-2 BNT162b2 mRNA vaccine (Pfizer/BioNTech). She donated her kidney to her husband 4 years ago. After receiving the 1st vaccine dose, she presented with nephrotic syndrome, with complete remission 5 days later. She proceeded with the second dose of the BNT162b2 vaccine at the appointed time. Two days later, she presented with a relapse of full-blown nephrotic syndrome with preserved renal function. We performed an ultrasound-guided percutaneous kidney biopsy and the final diagnosis was consistent with minimal change disease. Oral prednisolone was promptly initiated at a dosage of 1 mg/kg daily and complete remission was achieved 10 days later. More data about this rare appearance of de novo glomerular diseases after SARS-CoV-2 vaccination are emerging and should be interpreted rigorously.
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spelling pubmed-87791822022-01-22 De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor Marinaki, Smaragdi Kolovou, Kyriaki Liapis, George Skalioti, Chrysanthi Tsiakas, Stathis Boletis, Ioannis Medicina (Kaunas) Case Report Coronavirus disease 2019 has developed as a pandemic. Immunization with the introduction of vaccines against COVID-19 seems be the only way to end this pandemic. We report on a case of a kidney donor, who developed minimal change disease (MCD) within 4 days post-vaccination with the SARS-CoV-2 BNT162b2 mRNA vaccine (Pfizer/BioNTech). She donated her kidney to her husband 4 years ago. After receiving the 1st vaccine dose, she presented with nephrotic syndrome, with complete remission 5 days later. She proceeded with the second dose of the BNT162b2 vaccine at the appointed time. Two days later, she presented with a relapse of full-blown nephrotic syndrome with preserved renal function. We performed an ultrasound-guided percutaneous kidney biopsy and the final diagnosis was consistent with minimal change disease. Oral prednisolone was promptly initiated at a dosage of 1 mg/kg daily and complete remission was achieved 10 days later. More data about this rare appearance of de novo glomerular diseases after SARS-CoV-2 vaccination are emerging and should be interpreted rigorously. MDPI 2021-12-27 /pmc/articles/PMC8779182/ /pubmed/35056345 http://dx.doi.org/10.3390/medicina58010037 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Marinaki, Smaragdi
Kolovou, Kyriaki
Liapis, George
Skalioti, Chrysanthi
Tsiakas, Stathis
Boletis, Ioannis
De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title_full De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title_fullStr De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title_full_unstemmed De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title_short De Novo Minimal Change Disease following Vaccination with the Pfizer/BioNTech SARS-CoV-2 Vaccine in a Living Kidney Donor
title_sort de novo minimal change disease following vaccination with the pfizer/biontech sars-cov-2 vaccine in a living kidney donor
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779182/
https://www.ncbi.nlm.nih.gov/pubmed/35056345
http://dx.doi.org/10.3390/medicina58010037
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