A Concise Total Synthesis of the Fungal Isoquinoline Alkaloid TMC-120B

Recent reports of antiepileptic activity of the fungal alkaloid TMC-120B have renewed the interest in this natural product. Previous total syntheses of TMC-120B comprise many steps and have low overall yields (11–17 steps, 1.5–2.9% yield). Thus, to access this compound more efficiently, we herein pr...

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Detalles Bibliográficos
Autores principales: Haidar, Ahmad K., Kjeldsen, Niels D., Troelsen, Nikolaj S., Previtali, Viola, Lundquist, Kasper P., Larsen, Thomas O., Clausen, Mads H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779217/
https://www.ncbi.nlm.nih.gov/pubmed/35056832
http://dx.doi.org/10.3390/molecules27020521

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779217/
https://www.ncbi.nlm.nih.gov/pubmed/35056832
http://dx.doi.org/10.3390/molecules27020521

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