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Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics

In this study, well-known oligomers containing ethyl methacrylate (EMA) and glycidyl methacrylate (GMA) components for the synthesis of the oligomeric network [P(EMA)-co-(GMA)] were used. In order to change the hydrophobic character of the [P(EMA)-co-(GMA)] to a more hydrophilic one, the oligomeric...

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Autores principales: Chyzy, Adam, Pawelski, Damian, Vivcharenko, Vladyslav, Przekora, Agata, Bratychak, Michael, Astakhova, Olena, Breczko, Joanna, Drozdzal, Pawel, Plonska-Brzezinska, Marta E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779268/
https://www.ncbi.nlm.nih.gov/pubmed/35056652
http://dx.doi.org/10.3390/molecules27020337
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author Chyzy, Adam
Pawelski, Damian
Vivcharenko, Vladyslav
Przekora, Agata
Bratychak, Michael
Astakhova, Olena
Breczko, Joanna
Drozdzal, Pawel
Plonska-Brzezinska, Marta E.
author_facet Chyzy, Adam
Pawelski, Damian
Vivcharenko, Vladyslav
Przekora, Agata
Bratychak, Michael
Astakhova, Olena
Breczko, Joanna
Drozdzal, Pawel
Plonska-Brzezinska, Marta E.
author_sort Chyzy, Adam
collection PubMed
description In this study, well-known oligomers containing ethyl methacrylate (EMA) and glycidyl methacrylate (GMA) components for the synthesis of the oligomeric network [P(EMA)-co-(GMA)] were used. In order to change the hydrophobic character of the [P(EMA)-co-(GMA)] to a more hydrophilic one, the oligomeric chain was functionalized with ethanolamine, xylitol (Xyl), and L-ornithine. The oligomeric materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy, scanning electron microscopy, and differential thermogravimetric analysis. In the final stage, thanks to the large amount of -OH groups, it was possible to obtain a three-dimensional hydrogel (HG) network. The HGs were used as a matrix for the immobilization of methylene blue, which was chosen as a model compound of active substances, the release of which from the matrix was examined using spectrophotometric detection. The cytotoxic test was performed using fluid extracts of the HGs and human skin fibroblasts. The cell culture experiment showed that only [P(EMA)-co-(GMA)] and [P(EMA)-co-(GMA)]-Xyl have the potential to be used in biomedical applications. The studies revealed that the obtained HGs were porous and non-cytotoxic, which gives them the opportunity to possess great potential for use as an oligomeric network for drug reservoirs in in vitro application.
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spelling pubmed-87792682022-01-22 Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics Chyzy, Adam Pawelski, Damian Vivcharenko, Vladyslav Przekora, Agata Bratychak, Michael Astakhova, Olena Breczko, Joanna Drozdzal, Pawel Plonska-Brzezinska, Marta E. Molecules Article In this study, well-known oligomers containing ethyl methacrylate (EMA) and glycidyl methacrylate (GMA) components for the synthesis of the oligomeric network [P(EMA)-co-(GMA)] were used. In order to change the hydrophobic character of the [P(EMA)-co-(GMA)] to a more hydrophilic one, the oligomeric chain was functionalized with ethanolamine, xylitol (Xyl), and L-ornithine. The oligomeric materials were characterized by nuclear magnetic resonance and Fourier transform infrared spectroscopy, scanning electron microscopy, and differential thermogravimetric analysis. In the final stage, thanks to the large amount of -OH groups, it was possible to obtain a three-dimensional hydrogel (HG) network. The HGs were used as a matrix for the immobilization of methylene blue, which was chosen as a model compound of active substances, the release of which from the matrix was examined using spectrophotometric detection. The cytotoxic test was performed using fluid extracts of the HGs and human skin fibroblasts. The cell culture experiment showed that only [P(EMA)-co-(GMA)] and [P(EMA)-co-(GMA)]-Xyl have the potential to be used in biomedical applications. The studies revealed that the obtained HGs were porous and non-cytotoxic, which gives them the opportunity to possess great potential for use as an oligomeric network for drug reservoirs in in vitro application. MDPI 2022-01-06 /pmc/articles/PMC8779268/ /pubmed/35056652 http://dx.doi.org/10.3390/molecules27020337 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chyzy, Adam
Pawelski, Damian
Vivcharenko, Vladyslav
Przekora, Agata
Bratychak, Michael
Astakhova, Olena
Breczko, Joanna
Drozdzal, Pawel
Plonska-Brzezinska, Marta E.
Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title_full Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title_fullStr Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title_full_unstemmed Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title_short Microwave-Assisted Synthesis of Modified Glycidyl Methacrylate–Ethyl Methacrylate Oligomers, Their Physico-Chemical and Biological Characteristics
title_sort microwave-assisted synthesis of modified glycidyl methacrylate–ethyl methacrylate oligomers, their physico-chemical and biological characteristics
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779268/
https://www.ncbi.nlm.nih.gov/pubmed/35056652
http://dx.doi.org/10.3390/molecules27020337
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