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A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology

In recent years, there has been an increased interest in exploring the potential of micro-and mesoscale milling technologies for developing cost-effective microfluidic systems with high design flexibility and a rapid microfabrication process that does not require a cleanroom. Nevertheless, the numbe...

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Autores principales: Javidanbardan, Amin, Azevedo, Ana M., Chu, Virginia, Conde, João P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779272/
https://www.ncbi.nlm.nih.gov/pubmed/35056171
http://dx.doi.org/10.3390/mi13010006
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author Javidanbardan, Amin
Azevedo, Ana M.
Chu, Virginia
Conde, João P.
author_facet Javidanbardan, Amin
Azevedo, Ana M.
Chu, Virginia
Conde, João P.
author_sort Javidanbardan, Amin
collection PubMed
description In recent years, there has been an increased interest in exploring the potential of micro-and mesoscale milling technologies for developing cost-effective microfluidic systems with high design flexibility and a rapid microfabrication process that does not require a cleanroom. Nevertheless, the number of current studies aiming to fully understand and establish the benefits of this technique in developing high-quality microsystems with simple integrability is still limited. In the first part of this study, we define a systematic and adaptable strategy for developing high-quality poly(methyl methacrylate) (PMMA)-based micromilled structures. A case study of the average surface roughness (Ra) minimization of a cuboid column is presented to better illustrate some of the developed strategies. In this example, the Ra of a cuboid column was reduced from 1.68 μm to 0.223 μm by implementing milling optimization and postprocessing steps. In the second part of this paper, new strategies for developing a 3D microsystem were introduced by using a specifically designed negative PMMA master mold for polydimethylsiloxane (PDMS) double-casting prototyping. The reported results in this study demonstrate the robustness of the proposed approach for developing microfluidic structures with high surface quality and structural integrability in a reasonable amount of time.
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spelling pubmed-87792722022-01-22 A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology Javidanbardan, Amin Azevedo, Ana M. Chu, Virginia Conde, João P. Micromachines (Basel) Technical Note In recent years, there has been an increased interest in exploring the potential of micro-and mesoscale milling technologies for developing cost-effective microfluidic systems with high design flexibility and a rapid microfabrication process that does not require a cleanroom. Nevertheless, the number of current studies aiming to fully understand and establish the benefits of this technique in developing high-quality microsystems with simple integrability is still limited. In the first part of this study, we define a systematic and adaptable strategy for developing high-quality poly(methyl methacrylate) (PMMA)-based micromilled structures. A case study of the average surface roughness (Ra) minimization of a cuboid column is presented to better illustrate some of the developed strategies. In this example, the Ra of a cuboid column was reduced from 1.68 μm to 0.223 μm by implementing milling optimization and postprocessing steps. In the second part of this paper, new strategies for developing a 3D microsystem were introduced by using a specifically designed negative PMMA master mold for polydimethylsiloxane (PDMS) double-casting prototyping. The reported results in this study demonstrate the robustness of the proposed approach for developing microfluidic structures with high surface quality and structural integrability in a reasonable amount of time. MDPI 2021-12-22 /pmc/articles/PMC8779272/ /pubmed/35056171 http://dx.doi.org/10.3390/mi13010006 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Technical Note
Javidanbardan, Amin
Azevedo, Ana M.
Chu, Virginia
Conde, João P.
A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title_full A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title_fullStr A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title_full_unstemmed A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title_short A Systematic Approach for Developing 3D High-Quality PDMS Microfluidic Chips Based on Micromilling Technology
title_sort systematic approach for developing 3d high-quality pdms microfluidic chips based on micromilling technology
topic Technical Note
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779272/
https://www.ncbi.nlm.nih.gov/pubmed/35056171
http://dx.doi.org/10.3390/mi13010006
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