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Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study
(1) Background: A retrospective clinical study was conducted to compare the effectiveness of different pharmacological and non-pharmacological regimens for treating sudden sensorineural hearing loss (SSNHL). (2) Methods: Adult patients (n = 130) diagnosed with sudden sensorineural hearing loss (SSNH...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779405/ https://www.ncbi.nlm.nih.gov/pubmed/35054488 http://dx.doi.org/10.3390/life12010096 |
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author | Skarżyńska, Magdalena B. Kołodziejak, Aleksandra Gos, Elżbieta Sanfis, Milaine Dominici Skarżyński, Piotr H. |
author_facet | Skarżyńska, Magdalena B. Kołodziejak, Aleksandra Gos, Elżbieta Sanfis, Milaine Dominici Skarżyński, Piotr H. |
author_sort | Skarżyńska, Magdalena B. |
collection | PubMed |
description | (1) Background: A retrospective clinical study was conducted to compare the effectiveness of different pharmacological and non-pharmacological regimens for treating sudden sensorineural hearing loss (SSNHL). (2) Methods: Adult patients (n = 130) diagnosed with sudden sensorineural hearing loss (SSNHL) and hospitalized between 2015 and 2020 were enrolled in this study. Depending on the treatment regimen applied, patients were divided into five groups. Inclusion criteria were as follows: (i) hearing loss of sudden onset; (ii) hearing loss of at least 30 dB at three consecutive frequencies; (iii) unilateral hearing loss; (iv) age above 18 years. Exclusion criteria were as follows: (i) no follow-up audiogram; (ii) bilateral hearing loss; (iii) recognized alternative diagnosis such as tumor, disorder of inner ear fluids, infection or inflammation, autoimmune disease, malformation, hematological disease, dialysis-dependent renal failure, postdural puncture syndrome, gene-related syndrome, mitochondrial disease; and (iv) age below 18 years. (3) Results: Complete recovery was found in 14% of patients (18/130) and marked improvement was found in 6% (8/130), giving an overall success rate of 20%. The best results were obtained in the second group (i.e., patients given intratympanic glucocorticoid + prolonged orally administered glucocorticoid) where the success rate was 28%. In general, the older the patient, the smaller the improvement in hearing, a correlation that was statistically significant. (4) Conclusions: In treating SSNHL, the highest rate of hearing recovery—28%—was in the group of patients given intratympanic corticoid plus prolonged treatment with orally administered glucocorticoid. |
format | Online Article Text |
id | pubmed-8779405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87794052022-01-22 Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study Skarżyńska, Magdalena B. Kołodziejak, Aleksandra Gos, Elżbieta Sanfis, Milaine Dominici Skarżyński, Piotr H. Life (Basel) Article (1) Background: A retrospective clinical study was conducted to compare the effectiveness of different pharmacological and non-pharmacological regimens for treating sudden sensorineural hearing loss (SSNHL). (2) Methods: Adult patients (n = 130) diagnosed with sudden sensorineural hearing loss (SSNHL) and hospitalized between 2015 and 2020 were enrolled in this study. Depending on the treatment regimen applied, patients were divided into five groups. Inclusion criteria were as follows: (i) hearing loss of sudden onset; (ii) hearing loss of at least 30 dB at three consecutive frequencies; (iii) unilateral hearing loss; (iv) age above 18 years. Exclusion criteria were as follows: (i) no follow-up audiogram; (ii) bilateral hearing loss; (iii) recognized alternative diagnosis such as tumor, disorder of inner ear fluids, infection or inflammation, autoimmune disease, malformation, hematological disease, dialysis-dependent renal failure, postdural puncture syndrome, gene-related syndrome, mitochondrial disease; and (iv) age below 18 years. (3) Results: Complete recovery was found in 14% of patients (18/130) and marked improvement was found in 6% (8/130), giving an overall success rate of 20%. The best results were obtained in the second group (i.e., patients given intratympanic glucocorticoid + prolonged orally administered glucocorticoid) where the success rate was 28%. In general, the older the patient, the smaller the improvement in hearing, a correlation that was statistically significant. (4) Conclusions: In treating SSNHL, the highest rate of hearing recovery—28%—was in the group of patients given intratympanic corticoid plus prolonged treatment with orally administered glucocorticoid. MDPI 2022-01-10 /pmc/articles/PMC8779405/ /pubmed/35054488 http://dx.doi.org/10.3390/life12010096 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Skarżyńska, Magdalena B. Kołodziejak, Aleksandra Gos, Elżbieta Sanfis, Milaine Dominici Skarżyński, Piotr H. Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title | Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title_full | Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title_fullStr | Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title_full_unstemmed | Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title_short | Effectiveness of Various Treatments for Sudden Sensorineural Hearing Loss—A Retrospective Study |
title_sort | effectiveness of various treatments for sudden sensorineural hearing loss—a retrospective study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779405/ https://www.ncbi.nlm.nih.gov/pubmed/35054488 http://dx.doi.org/10.3390/life12010096 |
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