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Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions

Balloon-injured coronary segments are known to harbor abnormal vasomotion. We evaluated whether de novo coronary lesions treated using drug-coated balloon (DCB) are prone to vasospasm and how they respond to ergonovine and nitrate. Among 132 DCB angioplasty recipients followed, 89 patients underwent...

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Autores principales: Kim, Sunwon, Lee, Jong-Seok, Kim, Yong-Hyun, Kim, Jin-Seok, Lim, Sang-Yup, Kim, Seong Hwan, Kim, Minjung, Ahn, Jeong-Cheon, Song, Woo-Hyuk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779419/
https://www.ncbi.nlm.nih.gov/pubmed/35053994
http://dx.doi.org/10.3390/jcm11020299
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author Kim, Sunwon
Lee, Jong-Seok
Kim, Yong-Hyun
Kim, Jin-Seok
Lim, Sang-Yup
Kim, Seong Hwan
Kim, Minjung
Ahn, Jeong-Cheon
Song, Woo-Hyuk
author_facet Kim, Sunwon
Lee, Jong-Seok
Kim, Yong-Hyun
Kim, Jin-Seok
Lim, Sang-Yup
Kim, Seong Hwan
Kim, Minjung
Ahn, Jeong-Cheon
Song, Woo-Hyuk
author_sort Kim, Sunwon
collection PubMed
description Balloon-injured coronary segments are known to harbor abnormal vasomotion. We evaluated whether de novo coronary lesions treated using drug-coated balloon (DCB) are prone to vasospasm and how they respond to ergonovine and nitrate. Among 132 DCB angioplasty recipients followed, 89 patients underwent ergonovine provocation test at 6–9 months follow-up. Within-subject ergonovine- and nitrate-induced diameter changes were compared among three different sites: DCB-treated vs. angiographically normal vs. segment showing prominent vasoreactivity (spastic). No patient experienced clinically refractory vasospastic angina or symptom-driven revascularization during follow-up. Ergonovine induced vasospasm in seven patients; all were multifocal spasm either involving (n = 2) or rather sparing DCB-treated segments (n = 5). None showed focal spasm that exclusively involved DCB-treated lesions. Among 27 patients with vasospastic features, DCB-treated segments showed less vasoconstriction than spastic counterparts (p < 0.001). A total of 110 DCB-treated lesions were analyzed to assess vasomotor function. Vasomotor function, defined as a combined constrictor and dilator response, was comparable between DCB-treated and angiographically normal segments (p = 0.173), while significant differences were observed against spastic counterparts (p < 0.001). In our study, DCB-treated lesions were not particularly vulnerable to vasospasm and were found to have vasomotor function similar to angiographically normal segments, supporting safety of DCB-only strategy in treating de novo native coronary lesions.
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spelling pubmed-87794192022-01-22 Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions Kim, Sunwon Lee, Jong-Seok Kim, Yong-Hyun Kim, Jin-Seok Lim, Sang-Yup Kim, Seong Hwan Kim, Minjung Ahn, Jeong-Cheon Song, Woo-Hyuk J Clin Med Article Balloon-injured coronary segments are known to harbor abnormal vasomotion. We evaluated whether de novo coronary lesions treated using drug-coated balloon (DCB) are prone to vasospasm and how they respond to ergonovine and nitrate. Among 132 DCB angioplasty recipients followed, 89 patients underwent ergonovine provocation test at 6–9 months follow-up. Within-subject ergonovine- and nitrate-induced diameter changes were compared among three different sites: DCB-treated vs. angiographically normal vs. segment showing prominent vasoreactivity (spastic). No patient experienced clinically refractory vasospastic angina or symptom-driven revascularization during follow-up. Ergonovine induced vasospasm in seven patients; all were multifocal spasm either involving (n = 2) or rather sparing DCB-treated segments (n = 5). None showed focal spasm that exclusively involved DCB-treated lesions. Among 27 patients with vasospastic features, DCB-treated segments showed less vasoconstriction than spastic counterparts (p < 0.001). A total of 110 DCB-treated lesions were analyzed to assess vasomotor function. Vasomotor function, defined as a combined constrictor and dilator response, was comparable between DCB-treated and angiographically normal segments (p = 0.173), while significant differences were observed against spastic counterparts (p < 0.001). In our study, DCB-treated lesions were not particularly vulnerable to vasospasm and were found to have vasomotor function similar to angiographically normal segments, supporting safety of DCB-only strategy in treating de novo native coronary lesions. MDPI 2022-01-07 /pmc/articles/PMC8779419/ /pubmed/35053994 http://dx.doi.org/10.3390/jcm11020299 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Sunwon
Lee, Jong-Seok
Kim, Yong-Hyun
Kim, Jin-Seok
Lim, Sang-Yup
Kim, Seong Hwan
Kim, Minjung
Ahn, Jeong-Cheon
Song, Woo-Hyuk
Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title_full Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title_fullStr Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title_full_unstemmed Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title_short Favorable Vasomotor Function after Drug-Coated Balloon-Only Angioplasty of De Novo Native Coronary Artery Lesions
title_sort favorable vasomotor function after drug-coated balloon-only angioplasty of de novo native coronary artery lesions
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779419/
https://www.ncbi.nlm.nih.gov/pubmed/35053994
http://dx.doi.org/10.3390/jcm11020299
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