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HEK293T Cells with TFAM Disruption by CRISPR-Cas9 as a Model for Mitochondrial Regulation

The mitochondrial transcription factor A (TFAM) is considered a key factor in mitochondrial DNA (mtDNA) copy number. Given that the regulation of active copies of mtDNA is still not fully understood, we investigated the effects of CRISPR-Cas9 gene editing of TFAM in human embryonic kidney (HEK) 293T...

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Detalles Bibliográficos
Autores principales:	de Oliveira, Vanessa Cristina, Santos Roballo, Kelly Cristine, Mariano Junior, Clésio Gomes, Santos, Sarah Ingrid Pinto, Bressan, Fabiana Fernandes, Chiaratti, Marcos Roberto, Tucker, Elena J., Davis, Erica E., Concordet, Jean-Paul, Ambrósio, Carlos Eduardo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779421/ https://www.ncbi.nlm.nih.gov/pubmed/35054416 http://dx.doi.org/10.3390/life12010022

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