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CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer

Background: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospecti...

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Autores principales: Nam, Yunha, Choi, Chang-Min, Park, Young Soo, Jung, HyunA, Hwang, Hee Sang, Lee, Jae Cheol, Lee, Jung Wook, Lee, Jung Eun, Kang, Jung Hee, Jung, Byung Hun, Ji, Wonjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779436/
https://www.ncbi.nlm.nih.gov/pubmed/35054034
http://dx.doi.org/10.3390/jcm11020341
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author Nam, Yunha
Choi, Chang-Min
Park, Young Soo
Jung, HyunA
Hwang, Hee Sang
Lee, Jae Cheol
Lee, Jung Wook
Lee, Jung Eun
Kang, Jung Hee
Jung, Byung Hun
Ji, Wonjun
author_facet Nam, Yunha
Choi, Chang-Min
Park, Young Soo
Jung, HyunA
Hwang, Hee Sang
Lee, Jae Cheol
Lee, Jung Wook
Lee, Jung Eun
Kang, Jung Hee
Jung, Byung Hun
Ji, Wonjun
author_sort Nam, Yunha
collection PubMed
description Background: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospective study, we collected medical records of patients with NSCLC and matched tissue microarray blocks from surgical specimens. Semiquantitative immunohistochemistry was performed for measuring the expression level of fibroblast activation protein-alpha (FAP-α), Jagged-1 (JAG1), and CUB-domain-containing protein 1 (CDCP1). Results: A total of 453 patients who underwent complete resection between January 2011 and February 2012 were enrolled; 55.2% patients had stage I NSCLC, and 31.1% presented squamous cell carcinoma. Disease stage was a significant risk factor for recurrence and death, and age ≥ 65 years and male sex were associated with poor overall survival. FAP-a and JaG1 were not related to survivals, while CDCP1-expressing patients exhibited poor disease-free and overall survival. Moreover, CDCP1 expression in stage I NSCLC was significantly associated with recurrence. Conclusions: Old age, male sex, and high pathological stage were poor prognostic factors in patients with NSCLC who underwent surgical resection. Furthermore, CDCP1 expression could serve as a biomarker for poor prognosis in stage I NSCLC.
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spelling pubmed-87794362022-01-22 CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer Nam, Yunha Choi, Chang-Min Park, Young Soo Jung, HyunA Hwang, Hee Sang Lee, Jae Cheol Lee, Jung Wook Lee, Jung Eun Kang, Jung Hee Jung, Byung Hun Ji, Wonjun J Clin Med Article Background: Although early-stage lung cancer has increased owing to the introduction of screening programs, high recurrence rate remains a critical concern. We aimed to explore biomarkers related to the prognosis of surgically resected non-small-cell lung cancer (NSCLC). Methods: In this retrospective study, we collected medical records of patients with NSCLC and matched tissue microarray blocks from surgical specimens. Semiquantitative immunohistochemistry was performed for measuring the expression level of fibroblast activation protein-alpha (FAP-α), Jagged-1 (JAG1), and CUB-domain-containing protein 1 (CDCP1). Results: A total of 453 patients who underwent complete resection between January 2011 and February 2012 were enrolled; 55.2% patients had stage I NSCLC, and 31.1% presented squamous cell carcinoma. Disease stage was a significant risk factor for recurrence and death, and age ≥ 65 years and male sex were associated with poor overall survival. FAP-a and JaG1 were not related to survivals, while CDCP1-expressing patients exhibited poor disease-free and overall survival. Moreover, CDCP1 expression in stage I NSCLC was significantly associated with recurrence. Conclusions: Old age, male sex, and high pathological stage were poor prognostic factors in patients with NSCLC who underwent surgical resection. Furthermore, CDCP1 expression could serve as a biomarker for poor prognosis in stage I NSCLC. MDPI 2022-01-11 /pmc/articles/PMC8779436/ /pubmed/35054034 http://dx.doi.org/10.3390/jcm11020341 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Nam, Yunha
Choi, Chang-Min
Park, Young Soo
Jung, HyunA
Hwang, Hee Sang
Lee, Jae Cheol
Lee, Jung Wook
Lee, Jung Eun
Kang, Jung Hee
Jung, Byung Hun
Ji, Wonjun
CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title_full CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title_fullStr CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title_full_unstemmed CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title_short CDCP1 Expression Is a Potential Biomarker of Poor Prognosis in Resected Stage I Non-Small-Cell Lung Cancer
title_sort cdcp1 expression is a potential biomarker of poor prognosis in resected stage i non-small-cell lung cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779436/
https://www.ncbi.nlm.nih.gov/pubmed/35054034
http://dx.doi.org/10.3390/jcm11020341
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