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An Up-to-Date Review of Natural Nanoparticles for Cancer Management

Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology....

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Detalles Bibliográficos
Autores principales: Ion, Daniel, Niculescu, Adelina-Gabriela, Păduraru, Dan Nicolae, Andronic, Octavian, Mușat, Florentina, Grumezescu, Alexandru Mihai, Bolocan, Alexandra
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779479/
https://www.ncbi.nlm.nih.gov/pubmed/35056915
http://dx.doi.org/10.3390/pharmaceutics14010018
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author Ion, Daniel
Niculescu, Adelina-Gabriela
Păduraru, Dan Nicolae
Andronic, Octavian
Mușat, Florentina
Grumezescu, Alexandru Mihai
Bolocan, Alexandra
author_facet Ion, Daniel
Niculescu, Adelina-Gabriela
Păduraru, Dan Nicolae
Andronic, Octavian
Mușat, Florentina
Grumezescu, Alexandru Mihai
Bolocan, Alexandra
author_sort Ion, Daniel
collection PubMed
description Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology. Extensive research has been done for designing innovative nanoparticles able to specifically target tumor cells and ensure the controlled release of anticancer agents. To avoid the potential toxicity of synthetic materials, natural nanoparticles started to attract increasing scientific interest. In this context, this paper aims to review the most important natural nanoparticles used as active ingredients (e.g., polyphenols, polysaccharides, proteins, and sterol-like compounds) or as carriers (e.g., proteins, polysaccharides, viral nanoparticles, and exosomes) of various anticancer moieties, focusing on their recent applications in treating diverse malignancies.
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spelling pubmed-87794792022-01-22 An Up-to-Date Review of Natural Nanoparticles for Cancer Management Ion, Daniel Niculescu, Adelina-Gabriela Păduraru, Dan Nicolae Andronic, Octavian Mușat, Florentina Grumezescu, Alexandru Mihai Bolocan, Alexandra Pharmaceutics Review Cancer represents one of the leading causes of morbidity and mortality worldwide, imposing an urgent need to develop more efficient treatment alternatives. In this respect, much attention has been drawn from conventional cancer treatments to more modern approaches, such as the use of nanotechnology. Extensive research has been done for designing innovative nanoparticles able to specifically target tumor cells and ensure the controlled release of anticancer agents. To avoid the potential toxicity of synthetic materials, natural nanoparticles started to attract increasing scientific interest. In this context, this paper aims to review the most important natural nanoparticles used as active ingredients (e.g., polyphenols, polysaccharides, proteins, and sterol-like compounds) or as carriers (e.g., proteins, polysaccharides, viral nanoparticles, and exosomes) of various anticancer moieties, focusing on their recent applications in treating diverse malignancies. MDPI 2021-12-22 /pmc/articles/PMC8779479/ /pubmed/35056915 http://dx.doi.org/10.3390/pharmaceutics14010018 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ion, Daniel
Niculescu, Adelina-Gabriela
Păduraru, Dan Nicolae
Andronic, Octavian
Mușat, Florentina
Grumezescu, Alexandru Mihai
Bolocan, Alexandra
An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title_full An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title_fullStr An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title_full_unstemmed An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title_short An Up-to-Date Review of Natural Nanoparticles for Cancer Management
title_sort up-to-date review of natural nanoparticles for cancer management
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779479/
https://www.ncbi.nlm.nih.gov/pubmed/35056915
http://dx.doi.org/10.3390/pharmaceutics14010018
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