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The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress
The ability to respond to metabolic or environmental changes is an essential feature in all cells and involves both transcriptional and translational regulators that adjust the metabolic activity to fluctuating conditions. While transcriptional regulation has been studied in detail, the important ro...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779481/ https://www.ncbi.nlm.nih.gov/pubmed/35056463 http://dx.doi.org/10.3390/microorganisms10010014 |
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author | Landwehr, Victoria Milanov, Martin Hong, Jiang Koch, Hans-Georg |
author_facet | Landwehr, Victoria Milanov, Martin Hong, Jiang Koch, Hans-Georg |
author_sort | Landwehr, Victoria |
collection | PubMed |
description | The ability to respond to metabolic or environmental changes is an essential feature in all cells and involves both transcriptional and translational regulators that adjust the metabolic activity to fluctuating conditions. While transcriptional regulation has been studied in detail, the important role of the ribosome as an additional player in regulating gene expression is only beginning to emerge. Ribosome-interacting proteins are central to this translational regulation and include universally conserved ribosome interacting proteins, such as the ATPase YchF (Ola1 in eukaryotes). In both eukaryotes and bacteria, the cellular concentrations of YchF/Ola1 determine the ability to cope with different stress conditions and are linked to several pathologies in humans. The available data indicate that YchF/Ola1 regulates the stress response via controlling non-canonical translation initiation and via protein degradation. Although the molecular mechanisms appear to be different between bacteria and eukaryotes, increased non-canonical translation initiation is a common consequence of YchF/Ola1 regulated translational control in E. coli and H. sapiens. In this review, we summarize recent insights into the role of the universally conserved ATPase YchF/Ola1 in adapting translation to unfavourable conditions. |
format | Online Article Text |
id | pubmed-8779481 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87794812022-01-22 The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress Landwehr, Victoria Milanov, Martin Hong, Jiang Koch, Hans-Georg Microorganisms Review The ability to respond to metabolic or environmental changes is an essential feature in all cells and involves both transcriptional and translational regulators that adjust the metabolic activity to fluctuating conditions. While transcriptional regulation has been studied in detail, the important role of the ribosome as an additional player in regulating gene expression is only beginning to emerge. Ribosome-interacting proteins are central to this translational regulation and include universally conserved ribosome interacting proteins, such as the ATPase YchF (Ola1 in eukaryotes). In both eukaryotes and bacteria, the cellular concentrations of YchF/Ola1 determine the ability to cope with different stress conditions and are linked to several pathologies in humans. The available data indicate that YchF/Ola1 regulates the stress response via controlling non-canonical translation initiation and via protein degradation. Although the molecular mechanisms appear to be different between bacteria and eukaryotes, increased non-canonical translation initiation is a common consequence of YchF/Ola1 regulated translational control in E. coli and H. sapiens. In this review, we summarize recent insights into the role of the universally conserved ATPase YchF/Ola1 in adapting translation to unfavourable conditions. MDPI 2021-12-23 /pmc/articles/PMC8779481/ /pubmed/35056463 http://dx.doi.org/10.3390/microorganisms10010014 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Landwehr, Victoria Milanov, Martin Hong, Jiang Koch, Hans-Georg The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title | The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title_full | The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title_fullStr | The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title_full_unstemmed | The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title_short | The Role of the Universally Conserved ATPase YchF/Ola1 in Translation Regulation during Cellular Stress |
title_sort | role of the universally conserved atpase ychf/ola1 in translation regulation during cellular stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779481/ https://www.ncbi.nlm.nih.gov/pubmed/35056463 http://dx.doi.org/10.3390/microorganisms10010014 |
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