The Thiazole-5-Carboxamide GPS491 Inhibits HIV-1, Adenovirus, and Coronavirus Replication by Altering RNA Processing/Accumulation

Medicinal chemistry optimization of a previously described stilbene inhibitor of HIV-1, 5350150 (2-(2-(5-nitro-2-thienyl)vinyl)quinoline), led to the identification of the thiazole-5-carboxamide derivative (GPS491), which retained potent anti-HIV-1 activity with reduced toxicity. In this report, we...

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Detalles Bibliográficos
Autores principales: Dahal, Subha, Cheng, Ran, Cheung, Peter K., Been, Terek, Malty, Ramy, Geng, Melissa, Manianis, Sarah, Shkreta, Lulzim, Jahanshahi, Shahrazad, Toutant, Johanne, Chan, Rose, Park, Sean, Brockman, Mark A., Babu, Mohan, Mubareka, Samira, Mossman, Karen, Banerjee, Arinjay, Gray-Owen, Scott, Brown, Martha, Houry, Walid A., Chabot, Benoit, Grierson, David, Cochrane, Alan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779516/
https://www.ncbi.nlm.nih.gov/pubmed/35062264
http://dx.doi.org/10.3390/v14010060

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