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Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is...

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Autores principales: Park, Hyerin, Cho, Minkyoung, Do, Yoonju, Park, Jang-Kyung, Bae, Sung-Jin, Joo, Jongkil, Ha, Ki-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779555/
https://www.ncbi.nlm.nih.gov/pubmed/35056110
http://dx.doi.org/10.3390/ph15010053
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author Park, Hyerin
Cho, Minkyoung
Do, Yoonju
Park, Jang-Kyung
Bae, Sung-Jin
Joo, Jongkil
Ha, Ki-Tae
author_facet Park, Hyerin
Cho, Minkyoung
Do, Yoonju
Park, Jang-Kyung
Bae, Sung-Jin
Joo, Jongkil
Ha, Ki-Tae
author_sort Park, Hyerin
collection PubMed
description Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation.
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spelling pubmed-87795552022-01-22 Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation Park, Hyerin Cho, Minkyoung Do, Yoonju Park, Jang-Kyung Bae, Sung-Jin Joo, Jongkil Ha, Ki-Tae Pharmaceuticals (Basel) Review Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation. MDPI 2021-12-31 /pmc/articles/PMC8779555/ /pubmed/35056110 http://dx.doi.org/10.3390/ph15010053 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Park, Hyerin
Cho, Minkyoung
Do, Yoonju
Park, Jang-Kyung
Bae, Sung-Jin
Joo, Jongkil
Ha, Ki-Tae
Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title_full Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title_fullStr Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title_full_unstemmed Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title_short Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation
title_sort autophagy as a therapeutic target of natural products enhancing embryo implantation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779555/
https://www.ncbi.nlm.nih.gov/pubmed/35056110
http://dx.doi.org/10.3390/ph15010053
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