Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques

UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exp...

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Detalles Bibliográficos
Autores principales: Hipper, Elena, Blech, Michaela, Hinderberger, Dariush, Garidel, Patrick, Kaiser, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779573/
https://www.ncbi.nlm.nih.gov/pubmed/35056968
http://dx.doi.org/10.3390/pharmaceutics14010072
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author Hipper, Elena
Blech, Michaela
Hinderberger, Dariush
Garidel, Patrick
Kaiser, Wolfgang
author_facet Hipper, Elena
Blech, Michaela
Hinderberger, Dariush
Garidel, Patrick
Kaiser, Wolfgang
author_sort Hipper, Elena
collection PubMed
description UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques.
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spelling pubmed-87795732022-01-22 Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques Hipper, Elena Blech, Michaela Hinderberger, Dariush Garidel, Patrick Kaiser, Wolfgang Pharmaceutics Review UV and ambient light-induced modifications and related degradation of therapeutic proteins are observed during manufacturing and storage. Therefore, to ensure product quality, protein formulations need to be analyzed with respect to photo-degradation processes and eventually protected from light exposure. This task usually demands the application and combination of various analytical methods. This review addresses analytical aspects of investigating photo-oxidation products and related mediators such as reactive oxygen species generated via UV and ambient light with well-established and novel techniques. MDPI 2021-12-28 /pmc/articles/PMC8779573/ /pubmed/35056968 http://dx.doi.org/10.3390/pharmaceutics14010072 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hipper, Elena
Blech, Michaela
Hinderberger, Dariush
Garidel, Patrick
Kaiser, Wolfgang
Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title_full Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title_fullStr Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title_full_unstemmed Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title_short Photo-Oxidation of Therapeutic Protein Formulations: From Radical Formation to Analytical Techniques
title_sort photo-oxidation of therapeutic protein formulations: from radical formation to analytical techniques
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779573/
https://www.ncbi.nlm.nih.gov/pubmed/35056968
http://dx.doi.org/10.3390/pharmaceutics14010072
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AT garidelpatrick photooxidationoftherapeuticproteinformulationsfromradicalformationtoanalyticaltechniques
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