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Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception

The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regu...

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Autores principales: Troadec, Jean-Denis, Gaigé, Stéphanie, Barbot, Manon, Lebrun, Bruno, Barbouche, Rym, Abysique, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779587/
https://www.ncbi.nlm.nih.gov/pubmed/35055143
http://dx.doi.org/10.3390/ijms23020960
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author Troadec, Jean-Denis
Gaigé, Stéphanie
Barbot, Manon
Lebrun, Bruno
Barbouche, Rym
Abysique, Anne
author_facet Troadec, Jean-Denis
Gaigé, Stéphanie
Barbot, Manon
Lebrun, Bruno
Barbouche, Rym
Abysique, Anne
author_sort Troadec, Jean-Denis
collection PubMed
description The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level.
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spelling pubmed-87795872022-01-22 Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception Troadec, Jean-Denis Gaigé, Stéphanie Barbot, Manon Lebrun, Bruno Barbouche, Rym Abysique, Anne Int J Mol Sci Review The avoidance of being overweight or obese is a daily challenge for a growing number of people. The growing proportion of people suffering from a nutritional imbalance in many parts of the world exemplifies this challenge and emphasizes the need for a better understanding of the mechanisms that regulate nutritional balance. Until recently, research on the central regulation of food intake primarily focused on neuronal signaling, with little attention paid to the role of glial cells. Over the last few decades, our understanding of glial cells has changed dramatically. These cells are increasingly regarded as important neuronal partners, contributing not just to cerebral homeostasis, but also to cerebral signaling. Our understanding of the central regulation of energy balance is part of this (r)evolution. Evidence is accumulating that glial cells play a dynamic role in the modulation of energy balance. In the present review, we summarize recent data indicating that the multifaceted glial compartment of the brainstem dorsal vagal complex (DVC) should be considered in research aimed at identifying feeding-related processes operating at this level. MDPI 2022-01-16 /pmc/articles/PMC8779587/ /pubmed/35055143 http://dx.doi.org/10.3390/ijms23020960 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Troadec, Jean-Denis
Gaigé, Stéphanie
Barbot, Manon
Lebrun, Bruno
Barbouche, Rym
Abysique, Anne
Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title_full Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title_fullStr Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title_full_unstemmed Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title_short Glial Modulation of Energy Balance: The Dorsal Vagal Complex Is No Exception
title_sort glial modulation of energy balance: the dorsal vagal complex is no exception
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779587/
https://www.ncbi.nlm.nih.gov/pubmed/35055143
http://dx.doi.org/10.3390/ijms23020960
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