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Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites

Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF(3):Tb(3+) scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF(3):Tb(3+) nanopa...

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Autores principales: Polozhentsev, Oleg E., Pankin, Ilia A., Khodakova, Darya V., Medvedev, Pavel V., Goncharova, Anna S., Maksimov, Aleksey Yu., Kit, Oleg I., Soldatov, Alexander V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779613/
https://www.ncbi.nlm.nih.gov/pubmed/35057287
http://dx.doi.org/10.3390/ma15020569
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author Polozhentsev, Oleg E.
Pankin, Ilia A.
Khodakova, Darya V.
Medvedev, Pavel V.
Goncharova, Anna S.
Maksimov, Aleksey Yu.
Kit, Oleg I.
Soldatov, Alexander V.
author_facet Polozhentsev, Oleg E.
Pankin, Ilia A.
Khodakova, Darya V.
Medvedev, Pavel V.
Goncharova, Anna S.
Maksimov, Aleksey Yu.
Kit, Oleg I.
Soldatov, Alexander V.
author_sort Polozhentsev, Oleg E.
collection PubMed
description Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF(3):Tb(3+) scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF(3):Tb(3+) nanoparticles were synthesized by a facile and cost-effective wet chemical precipitation method. All synthesized nanoparticles had an elongated “spindle-like” clustered morphology with an orthorhombic structure. The structure, particle size, and morphology were determined by transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analysis. The presence of a polyethylene glycol (PEG) coating and Rose Bengal conjugates was proved by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and ultraviolet–visible (UV-vis) analysis. Upon X-ray irradiation of the colloidal PEG-capped GdF(3):Tb(3+)–Rose Bengal nanocomposite solution, an efficient fluorescent resonant energy transfer between scintillating nanoparticles and Rose Bengal was detected. The biodistribution of the synthesized nanoparticles in mice after intravenous administration was studied by in vivo CT imaging.
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spelling pubmed-87796132022-01-22 Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites Polozhentsev, Oleg E. Pankin, Ilia A. Khodakova, Darya V. Medvedev, Pavel V. Goncharova, Anna S. Maksimov, Aleksey Yu. Kit, Oleg I. Soldatov, Alexander V. Materials (Basel) Article Herein we report the development of a nanocomposite for X-ray-induced photodynamic therapy (X-PDT) and computed tomography (CT) based on PEG-capped GdF(3):Tb(3+) scintillating nanoparticles conjugated with Rose Bengal photosensitizer via electrostatic interactions. Scintillating GdF(3):Tb(3+) nanoparticles were synthesized by a facile and cost-effective wet chemical precipitation method. All synthesized nanoparticles had an elongated “spindle-like” clustered morphology with an orthorhombic structure. The structure, particle size, and morphology were determined by transmission electron microscopy (TEM), X-ray diffraction (XRD), and dynamic light scattering (DLS) analysis. The presence of a polyethylene glycol (PEG) coating and Rose Bengal conjugates was proved by Fourier-transform infrared spectroscopy (FTIR), thermogravimetric analysis (TG), and ultraviolet–visible (UV-vis) analysis. Upon X-ray irradiation of the colloidal PEG-capped GdF(3):Tb(3+)–Rose Bengal nanocomposite solution, an efficient fluorescent resonant energy transfer between scintillating nanoparticles and Rose Bengal was detected. The biodistribution of the synthesized nanoparticles in mice after intravenous administration was studied by in vivo CT imaging. MDPI 2022-01-13 /pmc/articles/PMC8779613/ /pubmed/35057287 http://dx.doi.org/10.3390/ma15020569 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Polozhentsev, Oleg E.
Pankin, Ilia A.
Khodakova, Darya V.
Medvedev, Pavel V.
Goncharova, Anna S.
Maksimov, Aleksey Yu.
Kit, Oleg I.
Soldatov, Alexander V.
Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title_full Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title_fullStr Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title_full_unstemmed Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title_short Synthesis, Characterization and Biodistribution of GdF(3):Tb(3+)@RB Nanocomposites
title_sort synthesis, characterization and biodistribution of gdf(3):tb(3+)@rb nanocomposites
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779613/
https://www.ncbi.nlm.nih.gov/pubmed/35057287
http://dx.doi.org/10.3390/ma15020569
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