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Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project

Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk of chronic disease. We hypothesized that dietary exposure to polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was to ev...

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Autores principales: Alonso-Pedrero, Lucia, Donat-Vargas, Carolina, Bes-Rastrollo, Maira, Ojeda-Rodríguez, Ana, Zalba, Guillermo, Razquin, Cristina, Martínez-González, Miguel A., Marti, Amelia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779661/
https://www.ncbi.nlm.nih.gov/pubmed/35057533
http://dx.doi.org/10.3390/nu14020353
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author Alonso-Pedrero, Lucia
Donat-Vargas, Carolina
Bes-Rastrollo, Maira
Ojeda-Rodríguez, Ana
Zalba, Guillermo
Razquin, Cristina
Martínez-González, Miguel A.
Marti, Amelia
author_facet Alonso-Pedrero, Lucia
Donat-Vargas, Carolina
Bes-Rastrollo, Maira
Ojeda-Rodríguez, Ana
Zalba, Guillermo
Razquin, Cristina
Martínez-González, Miguel A.
Marti, Amelia
author_sort Alonso-Pedrero, Lucia
collection PubMed
description Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk of chronic disease. We hypothesized that dietary exposure to polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was to evaluate the association of dietary exposure to PCBs and dioxins with TL. In this cross-sectional study of 886 subjects older than 55 y (mean age: 67.7; standard deviation (SD): 6.1; 27% women) from the “Seguimiento Universidad de Navarra” (SUN) project. TL was determined by real-time quantitative polymerase chain reaction and dietary PCBs and dioxins exposure was collected using a validated 136-item Food Frequency Questionnaire. Multivariable linear regression models were used to control for potential confounding factors. Shorter TL was associated with dietary total PCBs (SD of T/S ratio/(ng/day) = −0.30 × 10(−7); 95% CI, −0.55 × 10(−7) to −0.06 × 10(−7)), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO TEQ (Toxic Equivalents)/day) = −6.17 × 10(−7); 95% CI, −11.30 × 10(−7) to −1.03 × 10(−7)), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = −5.02 × 10(−7); 95% CI, −9.44 × 10(−7) to −0.61 × 10(−7)), but not with dioxins (SD of T/S ratio/(pg WHO TEQ/day) = −13.90 × 10(−7); 95% CI, −37.70 × 10(−7) to 9.79 × 10(−7)). In this sample of middle-aged and older Spanish adults, dietary exposure to total PCBs and DL-PCBs alone and together with dioxins was associated with shorter TL. Further longitudinal studies, preferably with POPs measured in biological samples, are needed to confirm this finding.
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spelling pubmed-87796612022-01-22 Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project Alonso-Pedrero, Lucia Donat-Vargas, Carolina Bes-Rastrollo, Maira Ojeda-Rodríguez, Ana Zalba, Guillermo Razquin, Cristina Martínez-González, Miguel A. Marti, Amelia Nutrients Article Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk of chronic disease. We hypothesized that dietary exposure to polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was to evaluate the association of dietary exposure to PCBs and dioxins with TL. In this cross-sectional study of 886 subjects older than 55 y (mean age: 67.7; standard deviation (SD): 6.1; 27% women) from the “Seguimiento Universidad de Navarra” (SUN) project. TL was determined by real-time quantitative polymerase chain reaction and dietary PCBs and dioxins exposure was collected using a validated 136-item Food Frequency Questionnaire. Multivariable linear regression models were used to control for potential confounding factors. Shorter TL was associated with dietary total PCBs (SD of T/S ratio/(ng/day) = −0.30 × 10(−7); 95% CI, −0.55 × 10(−7) to −0.06 × 10(−7)), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO TEQ (Toxic Equivalents)/day) = −6.17 × 10(−7); 95% CI, −11.30 × 10(−7) to −1.03 × 10(−7)), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = −5.02 × 10(−7); 95% CI, −9.44 × 10(−7) to −0.61 × 10(−7)), but not with dioxins (SD of T/S ratio/(pg WHO TEQ/day) = −13.90 × 10(−7); 95% CI, −37.70 × 10(−7) to 9.79 × 10(−7)). In this sample of middle-aged and older Spanish adults, dietary exposure to total PCBs and DL-PCBs alone and together with dioxins was associated with shorter TL. Further longitudinal studies, preferably with POPs measured in biological samples, are needed to confirm this finding. MDPI 2022-01-14 /pmc/articles/PMC8779661/ /pubmed/35057533 http://dx.doi.org/10.3390/nu14020353 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Alonso-Pedrero, Lucia
Donat-Vargas, Carolina
Bes-Rastrollo, Maira
Ojeda-Rodríguez, Ana
Zalba, Guillermo
Razquin, Cristina
Martínez-González, Miguel A.
Marti, Amelia
Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title_full Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title_fullStr Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title_full_unstemmed Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title_short Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project
title_sort dietary exposure to polychlorinated biphenyls and dioxins and its relationship to telomere length in subjects older than 55 years from the sun project
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779661/
https://www.ncbi.nlm.nih.gov/pubmed/35057533
http://dx.doi.org/10.3390/nu14020353
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