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Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study

The burden of COVID-19 has disproportionately impacted the elderly, who are at increased risk of severe disease, hospitalization, and death. This cross-sectional study aimed to assess the association between SARS-CoV-2 seroprevalence among nursing home staff, and cumulative incidence rates of COVID-...

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Autores principales: Wisniak, Ania, Menon, Lakshmi Krishna, Dumont, Roxane, Pullen, Nick, Regard, Simon, Dubos, Richard, Zaballa, María-Eugenia, Baysson, Hélène, Courvoisier, Delphine, Kaiser, Laurent, Pittet, Didier, Azman, Andrew S., Stringhini, Silvia, Guessous, Idris, Balavoine, Jean-François, Kherad, Omar
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779720/
https://www.ncbi.nlm.nih.gov/pubmed/35062247
http://dx.doi.org/10.3390/v14010043
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author Wisniak, Ania
Menon, Lakshmi Krishna
Dumont, Roxane
Pullen, Nick
Regard, Simon
Dubos, Richard
Zaballa, María-Eugenia
Baysson, Hélène
Courvoisier, Delphine
Kaiser, Laurent
Pittet, Didier
Azman, Andrew S.
Stringhini, Silvia
Guessous, Idris
Balavoine, Jean-François
Kherad, Omar
author_facet Wisniak, Ania
Menon, Lakshmi Krishna
Dumont, Roxane
Pullen, Nick
Regard, Simon
Dubos, Richard
Zaballa, María-Eugenia
Baysson, Hélène
Courvoisier, Delphine
Kaiser, Laurent
Pittet, Didier
Azman, Andrew S.
Stringhini, Silvia
Guessous, Idris
Balavoine, Jean-François
Kherad, Omar
author_sort Wisniak, Ania
collection PubMed
description The burden of COVID-19 has disproportionately impacted the elderly, who are at increased risk of severe disease, hospitalization, and death. This cross-sectional study aimed to assess the association between SARS-CoV-2 seroprevalence among nursing home staff, and cumulative incidence rates of COVID-19 cases, hospitalizations, and deaths among residents. Staff seroprevalence was estimated within the SEROCoV-WORK+ study between May and September 2020 across 29 nursing homes in Geneva, Switzerland. Data on nursing home residents were obtained from the canton of Geneva for the period between March and August 2020. Associations were assessed using Spearman’s correlation coefficient and quasi-Poisson regression models. Overall, seroprevalence among staff ranged between 0 and 31.4%, with a median of 8.3%. A positive association was found between staff seroprevalence and resident cumulative incidence of COVID-19 cases (correlation coefficient R = 0.72, 95%CI 0.45–0.87; incidence rate ratio [IRR] = 1.10, 95%CI 1.07–1.17), hospitalizations (R = 0.59, 95%CI 0.25–0.80; IRR = 1.09, 95%CI 1.05–1.13), and deaths (R = 0.71, 95%CI 0.44–0.86; IRR = 1.12, 95%CI 1.07–1.18). Our results suggest that SARS-CoV-2 transmission between staff and residents may contribute to the spread of the virus within nursing homes. Awareness among nursing home professionals of their likely role in the spread of SARS-CoV-2 has the potential to increase vaccination coverage and prevent unnecessary deaths due to COVID-19.
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spelling pubmed-87797202022-01-22 Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study Wisniak, Ania Menon, Lakshmi Krishna Dumont, Roxane Pullen, Nick Regard, Simon Dubos, Richard Zaballa, María-Eugenia Baysson, Hélène Courvoisier, Delphine Kaiser, Laurent Pittet, Didier Azman, Andrew S. Stringhini, Silvia Guessous, Idris Balavoine, Jean-François Kherad, Omar Viruses Article The burden of COVID-19 has disproportionately impacted the elderly, who are at increased risk of severe disease, hospitalization, and death. This cross-sectional study aimed to assess the association between SARS-CoV-2 seroprevalence among nursing home staff, and cumulative incidence rates of COVID-19 cases, hospitalizations, and deaths among residents. Staff seroprevalence was estimated within the SEROCoV-WORK+ study between May and September 2020 across 29 nursing homes in Geneva, Switzerland. Data on nursing home residents were obtained from the canton of Geneva for the period between March and August 2020. Associations were assessed using Spearman’s correlation coefficient and quasi-Poisson regression models. Overall, seroprevalence among staff ranged between 0 and 31.4%, with a median of 8.3%. A positive association was found between staff seroprevalence and resident cumulative incidence of COVID-19 cases (correlation coefficient R = 0.72, 95%CI 0.45–0.87; incidence rate ratio [IRR] = 1.10, 95%CI 1.07–1.17), hospitalizations (R = 0.59, 95%CI 0.25–0.80; IRR = 1.09, 95%CI 1.05–1.13), and deaths (R = 0.71, 95%CI 0.44–0.86; IRR = 1.12, 95%CI 1.07–1.18). Our results suggest that SARS-CoV-2 transmission between staff and residents may contribute to the spread of the virus within nursing homes. Awareness among nursing home professionals of their likely role in the spread of SARS-CoV-2 has the potential to increase vaccination coverage and prevent unnecessary deaths due to COVID-19. MDPI 2021-12-28 /pmc/articles/PMC8779720/ /pubmed/35062247 http://dx.doi.org/10.3390/v14010043 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Wisniak, Ania
Menon, Lakshmi Krishna
Dumont, Roxane
Pullen, Nick
Regard, Simon
Dubos, Richard
Zaballa, María-Eugenia
Baysson, Hélène
Courvoisier, Delphine
Kaiser, Laurent
Pittet, Didier
Azman, Andrew S.
Stringhini, Silvia
Guessous, Idris
Balavoine, Jean-François
Kherad, Omar
Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title_full Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title_fullStr Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title_full_unstemmed Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title_short Association between SARS-CoV-2 Seroprevalence in Nursing Home Staff and Resident COVID-19 Cases and Mortality: A Cross-Sectional Study
title_sort association between sars-cov-2 seroprevalence in nursing home staff and resident covid-19 cases and mortality: a cross-sectional study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779720/
https://www.ncbi.nlm.nih.gov/pubmed/35062247
http://dx.doi.org/10.3390/v14010043
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