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Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study

Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conven...

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Autores principales: Al-Taher, Mahdi, van den Bos, Jacqueline, Terink, Ivon, van Kuijk, Sander, van Hanegem, Nehalennia, Bouvy, Nicole, Bongers, Marlies, Stassen, Laurents, Lim, Arianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779744/
https://www.ncbi.nlm.nih.gov/pubmed/35054408
http://dx.doi.org/10.3390/life12010015
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author Al-Taher, Mahdi
van den Bos, Jacqueline
Terink, Ivon
van Kuijk, Sander
van Hanegem, Nehalennia
Bouvy, Nicole
Bongers, Marlies
Stassen, Laurents
Lim, Arianne
author_facet Al-Taher, Mahdi
van den Bos, Jacqueline
Terink, Ivon
van Kuijk, Sander
van Hanegem, Nehalennia
Bouvy, Nicole
Bongers, Marlies
Stassen, Laurents
Lim, Arianne
author_sort Al-Taher, Mahdi
collection PubMed
description Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions.
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spelling pubmed-87797442022-01-22 Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study Al-Taher, Mahdi van den Bos, Jacqueline Terink, Ivon van Kuijk, Sander van Hanegem, Nehalennia Bouvy, Nicole Bongers, Marlies Stassen, Laurents Lim, Arianne Life (Basel) Article Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions. MDPI 2021-12-23 /pmc/articles/PMC8779744/ /pubmed/35054408 http://dx.doi.org/10.3390/life12010015 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Al-Taher, Mahdi
van den Bos, Jacqueline
Terink, Ivon
van Kuijk, Sander
van Hanegem, Nehalennia
Bouvy, Nicole
Bongers, Marlies
Stassen, Laurents
Lim, Arianne
Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title_full Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title_fullStr Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title_full_unstemmed Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title_short Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
title_sort near-infrared fluorescence imaging for the intraoperative detection of endometriosis: a pilot study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779744/
https://www.ncbi.nlm.nih.gov/pubmed/35054408
http://dx.doi.org/10.3390/life12010015
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