Cargando…
Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study
Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conven...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779744/ https://www.ncbi.nlm.nih.gov/pubmed/35054408 http://dx.doi.org/10.3390/life12010015 |
_version_ | 1784637652544258048 |
---|---|
author | Al-Taher, Mahdi van den Bos, Jacqueline Terink, Ivon van Kuijk, Sander van Hanegem, Nehalennia Bouvy, Nicole Bongers, Marlies Stassen, Laurents Lim, Arianne |
author_facet | Al-Taher, Mahdi van den Bos, Jacqueline Terink, Ivon van Kuijk, Sander van Hanegem, Nehalennia Bouvy, Nicole Bongers, Marlies Stassen, Laurents Lim, Arianne |
author_sort | Al-Taher, Mahdi |
collection | PubMed |
description | Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions. |
format | Online Article Text |
id | pubmed-8779744 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87797442022-01-22 Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study Al-Taher, Mahdi van den Bos, Jacqueline Terink, Ivon van Kuijk, Sander van Hanegem, Nehalennia Bouvy, Nicole Bongers, Marlies Stassen, Laurents Lim, Arianne Life (Basel) Article Introduction: Endometriosis surgery is associated with a high risk of reoperation due to an insufficient recognition of endometriotic lesions. Our aim was to explore the role of near-infrared fluorescence (NIRF) imaging for the visualization and identification of endometriotic lesions next to conventional white light (WL) laparoscopy. Materials and methods: Fifteen women scheduled for diagnostic laparoscopy in whom peritoneal endometriosis was suspected were included. Peritoneal exploration was performed in WL, followed by NIRF imaging after ICG administration. Biopsies of all the suspected lesions were taken for histological examination. Subjective evaluations of the equipment and NIRF imaging were also performed. Results: Only 61% (44) of the biopsied lesions contained endometriosis. The positive predictive value (PPV) for the lesions found in WL was 64%. The PPV for the lesions found under NIRF was 69% and the PPV for the lesions found in both modes was 61%. The mean satisfaction of surgeons regarding the surgical procedure and equipment using both imaging modalities was 6.5 (p > 0.05) on a 10 item Likert scale and the mean satisfaction with the quality of the NIRF imaging was 7.4 (p > 0.05). Conclusion: In this study, the additional value of NIRF imaging, although feasible, was found to be limited for the intraoperative detection of endometriotic lesions. MDPI 2021-12-23 /pmc/articles/PMC8779744/ /pubmed/35054408 http://dx.doi.org/10.3390/life12010015 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Al-Taher, Mahdi van den Bos, Jacqueline Terink, Ivon van Kuijk, Sander van Hanegem, Nehalennia Bouvy, Nicole Bongers, Marlies Stassen, Laurents Lim, Arianne Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title | Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title_full | Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title_fullStr | Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title_full_unstemmed | Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title_short | Near-Infrared Fluorescence Imaging for the Intraoperative Detection of Endometriosis: A Pilot Study |
title_sort | near-infrared fluorescence imaging for the intraoperative detection of endometriosis: a pilot study |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779744/ https://www.ncbi.nlm.nih.gov/pubmed/35054408 http://dx.doi.org/10.3390/life12010015 |
work_keys_str_mv | AT altahermahdi nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT vandenbosjacqueline nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT terinkivon nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT vankuijksander nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT vanhanegemnehalennia nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT bouvynicole nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT bongersmarlies nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT stassenlaurents nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy AT limarianne nearinfraredfluorescenceimagingfortheintraoperativedetectionofendometriosisapilotstudy |