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Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats

The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates...

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Autores principales: Carvalho, Andrey Vinicios S., Ribeiro, Rafael T., Durán-Carabali, Luz Elena, Martini, Ana Paula R., Hoeper, Eduarda, Sanches, Eduardo F., Konrath, Eduardo Luis, Dalmaz, Carla, Wajner, Moacir, Netto, Carlos Alexandre
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779767/
https://www.ncbi.nlm.nih.gov/pubmed/35057576
http://dx.doi.org/10.3390/nu14020395
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author Carvalho, Andrey Vinicios S.
Ribeiro, Rafael T.
Durán-Carabali, Luz Elena
Martini, Ana Paula R.
Hoeper, Eduarda
Sanches, Eduardo F.
Konrath, Eduardo Luis
Dalmaz, Carla
Wajner, Moacir
Netto, Carlos Alexandre
author_facet Carvalho, Andrey Vinicios S.
Ribeiro, Rafael T.
Durán-Carabali, Luz Elena
Martini, Ana Paula R.
Hoeper, Eduarda
Sanches, Eduardo F.
Konrath, Eduardo Luis
Dalmaz, Carla
Wajner, Moacir
Netto, Carlos Alexandre
author_sort Carvalho, Andrey Vinicios S.
collection PubMed
description The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the Plinia trunciflora fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1β in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia–ischemia.
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spelling pubmed-87797672022-01-22 Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats Carvalho, Andrey Vinicios S. Ribeiro, Rafael T. Durán-Carabali, Luz Elena Martini, Ana Paula R. Hoeper, Eduarda Sanches, Eduardo F. Konrath, Eduardo Luis Dalmaz, Carla Wajner, Moacir Netto, Carlos Alexandre Nutrients Article The disruption of redox homeostasis and neuroinflammation are key mechanisms in the pathogenesis of brain hypoxia–ischemia (HI); medicinal plants have been studied as a therapeutic strategy, generally associated with the prevention of oxidative stress and inflammatory response. This study evaluates the neuroprotective role of the Plinia trunciflora fruit extract (PTE) in neonatal rats submitted to experimental HI. The HI insult provoked a marked increase in the lipoperoxidation levels and glutathione peroxidase (GPx) activity, accompanied by a decrease in the brain concentration of glutathione (GSH). Interestingly, PTE was able to prevent most of the HI-induced pro-oxidant effects. It was also observed that HI increased the levels of interleukin-1β in the hippocampus, and that PTE-treatment prevented this effect. Furthermore, PTE was able to prevent neuronal loss and astrocyte reactivity induced by HI, as demonstrated by NeuN and GFAP staining, respectively. PTE also attenuated the anxiety-like behavior and prevented the spatial memory impairment caused by HI. Finally, PTE prevented neural tissue loss in the brain hemisphere, the hippocampus, cerebral cortex, and the striatum ipsilateral to the HI. Taken together our results provide good evidence that the PTE extract has the potential to be investigated as an adjunctive therapy in the treatment of brain insult caused by neonatal hypoxia–ischemia. MDPI 2022-01-17 /pmc/articles/PMC8779767/ /pubmed/35057576 http://dx.doi.org/10.3390/nu14020395 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Carvalho, Andrey Vinicios S.
Ribeiro, Rafael T.
Durán-Carabali, Luz Elena
Martini, Ana Paula R.
Hoeper, Eduarda
Sanches, Eduardo F.
Konrath, Eduardo Luis
Dalmaz, Carla
Wajner, Moacir
Netto, Carlos Alexandre
Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title_full Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title_fullStr Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title_full_unstemmed Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title_short Plinia trunciflora Extract Administration Prevents HI-Induced Oxidative Stress, Inflammatory Response, Behavioral Impairments, and Tissue Damage in Rats
title_sort plinia trunciflora extract administration prevents hi-induced oxidative stress, inflammatory response, behavioral impairments, and tissue damage in rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779767/
https://www.ncbi.nlm.nih.gov/pubmed/35057576
http://dx.doi.org/10.3390/nu14020395
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