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Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department

Detecting sepsis patients who are at a high-risk of mechanical ventilation is important in emergency departments (ED). The respiratory rate oxygenation (ROX) index is the ratio of tissue oxygen saturation/fraction of inspired oxygen to the respiratory rate. This study aimed to investigate whether th...

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Autores principales: Ahn, Sejoong, Park, Jonghak, Song, Juhyun, Kim, Jooyeong, Cho, Hanjin, Moon, Sungwoo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779773/
https://www.ncbi.nlm.nih.gov/pubmed/35054035
http://dx.doi.org/10.3390/jcm11020342
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author Ahn, Sejoong
Park, Jonghak
Song, Juhyun
Kim, Jooyeong
Cho, Hanjin
Moon, Sungwoo
author_facet Ahn, Sejoong
Park, Jonghak
Song, Juhyun
Kim, Jooyeong
Cho, Hanjin
Moon, Sungwoo
author_sort Ahn, Sejoong
collection PubMed
description Detecting sepsis patients who are at a high-risk of mechanical ventilation is important in emergency departments (ED). The respiratory rate oxygenation (ROX) index is the ratio of tissue oxygen saturation/fraction of inspired oxygen to the respiratory rate. This study aimed to investigate whether the ROX index could predict mechanical ventilator use in sepsis patients in an ED. This retrospective observational study included quick sequential organ failure assessment (qSOFA) ≥ 2 sepsis patients that presented to the ED between September 2019 and April 2020. The ROX and ROX-heart rate (HR) indices were significantly lower in patients with mechanical ventilator use within 24 h than in those without the use of a mechanical ventilator (4.0 [3.2–5.4] vs. 10.0 [5.9–15.2], p < 0.001 and 3.9 [2.7–5.8] vs. 10.1 [5.4–16.3], p < 0.001, respectively). The area under the receiver operating characteristic (ROC) curve of the ROX and ROX-HR indices were 0.854 and 0.816 (both p < 0.001). The ROX and ROX-HR indices were independently associated with mechanical ventilator use within 24 h (adjusted hazard ratio = 0.78, 95% CI: 0.68–0.90, p < 0.001 and adjusted hazard ratio = 0.87, 95% CI 0.79–0.96, p = 0.004, respectively). The 28-day mortality was higher in the low ROX and low ROX-HR groups. The ROX and ROX-HR indices were associated with mechanical ventilator use within 24 h in qSOFA ≥ 2 patients in the ED.
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spelling pubmed-87797732022-01-22 Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department Ahn, Sejoong Park, Jonghak Song, Juhyun Kim, Jooyeong Cho, Hanjin Moon, Sungwoo J Clin Med Article Detecting sepsis patients who are at a high-risk of mechanical ventilation is important in emergency departments (ED). The respiratory rate oxygenation (ROX) index is the ratio of tissue oxygen saturation/fraction of inspired oxygen to the respiratory rate. This study aimed to investigate whether the ROX index could predict mechanical ventilator use in sepsis patients in an ED. This retrospective observational study included quick sequential organ failure assessment (qSOFA) ≥ 2 sepsis patients that presented to the ED between September 2019 and April 2020. The ROX and ROX-heart rate (HR) indices were significantly lower in patients with mechanical ventilator use within 24 h than in those without the use of a mechanical ventilator (4.0 [3.2–5.4] vs. 10.0 [5.9–15.2], p < 0.001 and 3.9 [2.7–5.8] vs. 10.1 [5.4–16.3], p < 0.001, respectively). The area under the receiver operating characteristic (ROC) curve of the ROX and ROX-HR indices were 0.854 and 0.816 (both p < 0.001). The ROX and ROX-HR indices were independently associated with mechanical ventilator use within 24 h (adjusted hazard ratio = 0.78, 95% CI: 0.68–0.90, p < 0.001 and adjusted hazard ratio = 0.87, 95% CI 0.79–0.96, p = 0.004, respectively). The 28-day mortality was higher in the low ROX and low ROX-HR groups. The ROX and ROX-HR indices were associated with mechanical ventilator use within 24 h in qSOFA ≥ 2 patients in the ED. MDPI 2022-01-11 /pmc/articles/PMC8779773/ /pubmed/35054035 http://dx.doi.org/10.3390/jcm11020342 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ahn, Sejoong
Park, Jonghak
Song, Juhyun
Kim, Jooyeong
Cho, Hanjin
Moon, Sungwoo
Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title_full Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title_fullStr Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title_full_unstemmed Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title_short Association of ROX Index with Mechanical Ventilator Use in Sepsis Patients in the Emergency Department
title_sort association of rox index with mechanical ventilator use in sepsis patients in the emergency department
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779773/
https://www.ncbi.nlm.nih.gov/pubmed/35054035
http://dx.doi.org/10.3390/jcm11020342
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