Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides

Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities...

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Autores principales: Cheng, Ming-Jen, Wu, Ming-Der, Chang, Chao-Lin, Chang, Hsun-Shuo, Chyu, Chiou-Fung, Kuo, Yueh-Hsiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779853/
https://www.ncbi.nlm.nih.gov/pubmed/35056749
http://dx.doi.org/10.3390/molecules27020437
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author Cheng, Ming-Jen
Wu, Ming-Der
Chang, Chao-Lin
Chang, Hsun-Shuo
Chyu, Chiou-Fung
Kuo, Yueh-Hsiung
author_facet Cheng, Ming-Jen
Wu, Ming-Der
Chang, Chao-Lin
Chang, Hsun-Shuo
Chyu, Chiou-Fung
Kuo, Yueh-Hsiung
author_sort Cheng, Ming-Jen
collection PubMed
description Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae.
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spelling pubmed-87798532022-01-22 Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides Cheng, Ming-Jen Wu, Ming-Der Chang, Chao-Lin Chang, Hsun-Shuo Chyu, Chiou-Fung Kuo, Yueh-Hsiung Molecules Article Five new dimer compounds, namely Taiwaniacryptodimers A–E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae. MDPI 2022-01-10 /pmc/articles/PMC8779853/ /pubmed/35056749 http://dx.doi.org/10.3390/molecules27020437 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Cheng, Ming-Jen
Wu, Ming-Der
Chang, Chao-Lin
Chang, Hsun-Shuo
Chyu, Chiou-Fung
Kuo, Yueh-Hsiung
Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title_full Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title_fullStr Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title_full_unstemmed Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title_short Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides
title_sort novel antifungal dimers from the roots of taiwania cryptomerioides
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779853/
https://www.ncbi.nlm.nih.gov/pubmed/35056749
http://dx.doi.org/10.3390/molecules27020437
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