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Coupling Bulk Phase Separation of Disordered Proteins to Membrane Domain Formation in Molecular Simulations on a Bespoke Compute Fabric
Phospholipid membranes surround the cell and its internal organelles, and their multicomponent nature allows the formation of domains that are important in cellular signalling, the immune system, and bacterial infection. Cytoplasmic compartments are also created by the phase separation of intrinsica...
Autores principales: | Shillcock, Julian C., Thomas, David B., Beaumont, Jonathan R., Bragg, Graeme M., Vousden, Mark L., Brown, Andrew D. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779898/ https://www.ncbi.nlm.nih.gov/pubmed/35054543 http://dx.doi.org/10.3390/membranes12010017 |
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