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Deep-Learning Based Estimation of Dielectrophoretic Force
The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microp...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779967/ https://www.ncbi.nlm.nih.gov/pubmed/35056207 http://dx.doi.org/10.3390/mi13010041 |
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author | Ajala, Sunday Jalajamony, Harikrishnan Muraleedharan Fernandez, Renny Edwin |
author_facet | Ajala, Sunday Jalajamony, Harikrishnan Muraleedharan Fernandez, Renny Edwin |
author_sort | Ajala, Sunday |
collection | PubMed |
description | The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microparticles. We demonstrate how our deep learning model can process micrographs of pearl chains of polystyrene (PS) microbeads to estimate the DEP forces experienced. Numerous images obtained from our experiments at varying input voltages were preprocessed and used to train three deep convolutional neural networks, namely AlexNet, MobileNetV2, and VGG19. The performances of all the models was tested for their validation accuracies. Models were also tested with adversarial images to evaluate performance in terms of classification accuracy and resilience as a result of noise, image blur, and contrast changes. The results indicated that our method is robust under unfavorable real-world settings, demonstrating that it can be used for the direct estimation of dielectrophoretic force in point-of-care settings. |
format | Online Article Text |
id | pubmed-8779967 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87799672022-01-22 Deep-Learning Based Estimation of Dielectrophoretic Force Ajala, Sunday Jalajamony, Harikrishnan Muraleedharan Fernandez, Renny Edwin Micromachines (Basel) Article The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microparticles. We demonstrate how our deep learning model can process micrographs of pearl chains of polystyrene (PS) microbeads to estimate the DEP forces experienced. Numerous images obtained from our experiments at varying input voltages were preprocessed and used to train three deep convolutional neural networks, namely AlexNet, MobileNetV2, and VGG19. The performances of all the models was tested for their validation accuracies. Models were also tested with adversarial images to evaluate performance in terms of classification accuracy and resilience as a result of noise, image blur, and contrast changes. The results indicated that our method is robust under unfavorable real-world settings, demonstrating that it can be used for the direct estimation of dielectrophoretic force in point-of-care settings. MDPI 2021-12-28 /pmc/articles/PMC8779967/ /pubmed/35056207 http://dx.doi.org/10.3390/mi13010041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Ajala, Sunday Jalajamony, Harikrishnan Muraleedharan Fernandez, Renny Edwin Deep-Learning Based Estimation of Dielectrophoretic Force |
title | Deep-Learning Based Estimation of Dielectrophoretic Force |
title_full | Deep-Learning Based Estimation of Dielectrophoretic Force |
title_fullStr | Deep-Learning Based Estimation of Dielectrophoretic Force |
title_full_unstemmed | Deep-Learning Based Estimation of Dielectrophoretic Force |
title_short | Deep-Learning Based Estimation of Dielectrophoretic Force |
title_sort | deep-learning based estimation of dielectrophoretic force |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779967/ https://www.ncbi.nlm.nih.gov/pubmed/35056207 http://dx.doi.org/10.3390/mi13010041 |
work_keys_str_mv | AT ajalasunday deeplearningbasedestimationofdielectrophoreticforce AT jalajamonyharikrishnanmuraleedharan deeplearningbasedestimationofdielectrophoreticforce AT fernandezrennyedwin deeplearningbasedestimationofdielectrophoreticforce |