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Deep-Learning Based Estimation of Dielectrophoretic Force

The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microp...

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Autores principales: Ajala, Sunday, Jalajamony, Harikrishnan Muraleedharan, Fernandez, Renny Edwin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779967/
https://www.ncbi.nlm.nih.gov/pubmed/35056207
http://dx.doi.org/10.3390/mi13010041
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author Ajala, Sunday
Jalajamony, Harikrishnan Muraleedharan
Fernandez, Renny Edwin
author_facet Ajala, Sunday
Jalajamony, Harikrishnan Muraleedharan
Fernandez, Renny Edwin
author_sort Ajala, Sunday
collection PubMed
description The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microparticles. We demonstrate how our deep learning model can process micrographs of pearl chains of polystyrene (PS) microbeads to estimate the DEP forces experienced. Numerous images obtained from our experiments at varying input voltages were preprocessed and used to train three deep convolutional neural networks, namely AlexNet, MobileNetV2, and VGG19. The performances of all the models was tested for their validation accuracies. Models were also tested with adversarial images to evaluate performance in terms of classification accuracy and resilience as a result of noise, image blur, and contrast changes. The results indicated that our method is robust under unfavorable real-world settings, demonstrating that it can be used for the direct estimation of dielectrophoretic force in point-of-care settings.
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spelling pubmed-87799672022-01-22 Deep-Learning Based Estimation of Dielectrophoretic Force Ajala, Sunday Jalajamony, Harikrishnan Muraleedharan Fernandez, Renny Edwin Micromachines (Basel) Article The ability to accurately quantify dielectrophoretic (DEP) force is critical in the development of high-efficiency microfluidic systems. This is the first reported work that combines a textile electrode-based DEP sensing system with deep learning in order to estimate the DEP forces invoked on microparticles. We demonstrate how our deep learning model can process micrographs of pearl chains of polystyrene (PS) microbeads to estimate the DEP forces experienced. Numerous images obtained from our experiments at varying input voltages were preprocessed and used to train three deep convolutional neural networks, namely AlexNet, MobileNetV2, and VGG19. The performances of all the models was tested for their validation accuracies. Models were also tested with adversarial images to evaluate performance in terms of classification accuracy and resilience as a result of noise, image blur, and contrast changes. The results indicated that our method is robust under unfavorable real-world settings, demonstrating that it can be used for the direct estimation of dielectrophoretic force in point-of-care settings. MDPI 2021-12-28 /pmc/articles/PMC8779967/ /pubmed/35056207 http://dx.doi.org/10.3390/mi13010041 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ajala, Sunday
Jalajamony, Harikrishnan Muraleedharan
Fernandez, Renny Edwin
Deep-Learning Based Estimation of Dielectrophoretic Force
title Deep-Learning Based Estimation of Dielectrophoretic Force
title_full Deep-Learning Based Estimation of Dielectrophoretic Force
title_fullStr Deep-Learning Based Estimation of Dielectrophoretic Force
title_full_unstemmed Deep-Learning Based Estimation of Dielectrophoretic Force
title_short Deep-Learning Based Estimation of Dielectrophoretic Force
title_sort deep-learning based estimation of dielectrophoretic force
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779967/
https://www.ncbi.nlm.nih.gov/pubmed/35056207
http://dx.doi.org/10.3390/mi13010041
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