Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots

In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface mod...

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Autores principales: Korolev, Dmitry V., Shulmeyster, Galina A., Evreinova, Natalia V., Syrovatkina, Maria S., Istomina, Maria S., Postnov, Victor N., Aleksandrov, Ilia V., Krasichkov, Aleksandr S., Galagudza, Michael M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779983/
https://www.ncbi.nlm.nih.gov/pubmed/35055120
http://dx.doi.org/10.3390/ijms23020932
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author Korolev, Dmitry V.
Shulmeyster, Galina A.
Evreinova, Natalia V.
Syrovatkina, Maria S.
Istomina, Maria S.
Postnov, Victor N.
Aleksandrov, Ilia V.
Krasichkov, Aleksandr S.
Galagudza, Michael M.
author_facet Korolev, Dmitry V.
Shulmeyster, Galina A.
Evreinova, Natalia V.
Syrovatkina, Maria S.
Istomina, Maria S.
Postnov, Victor N.
Aleksandrov, Ilia V.
Krasichkov, Aleksandr S.
Galagudza, Michael M.
author_sort Korolev, Dmitry V.
collection PubMed
description In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS(2)/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals.
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spelling pubmed-87799832022-01-22 Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots Korolev, Dmitry V. Shulmeyster, Galina A. Evreinova, Natalia V. Syrovatkina, Maria S. Istomina, Maria S. Postnov, Victor N. Aleksandrov, Ilia V. Krasichkov, Aleksandr S. Galagudza, Michael M. Int J Mol Sci Article In this paper, we describe the synthesis of multilayer nanoparticles as a platform for the diagnosis and treatment of ischemic injuries. The platform is based on magnetite (MNP) and silica (SNP) nanoparticles, while quinacrine is used as an anti-ischemic agent. The synthesis includes the surface modification of nanoparticles with (3-glycidyloxypropyl)trimethoxysilane (GPMS), the immobilization of quinacrine, and the formation of a chitosan coating, which is used to fix the fluorophore indocyanine green (ICG) and colloidal quantum dots AgInS(2)/ZnS (CQDs), which serve as secondary radiation sources. The potential theranostic platform was studied in laboratory animals. MDPI 2022-01-15 /pmc/articles/PMC8779983/ /pubmed/35055120 http://dx.doi.org/10.3390/ijms23020932 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Korolev, Dmitry V.
Shulmeyster, Galina A.
Evreinova, Natalia V.
Syrovatkina, Maria S.
Istomina, Maria S.
Postnov, Victor N.
Aleksandrov, Ilia V.
Krasichkov, Aleksandr S.
Galagudza, Michael M.
Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title_full Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title_fullStr Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title_full_unstemmed Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title_short Theranostic Platforms Based on Silica and Magnetic Nanoparticles Containing Quinacrine, Chitosan, Fluorophores, and Quantum Dots
title_sort theranostic platforms based on silica and magnetic nanoparticles containing quinacrine, chitosan, fluorophores, and quantum dots
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8779983/
https://www.ncbi.nlm.nih.gov/pubmed/35055120
http://dx.doi.org/10.3390/ijms23020932
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