Cargando…

Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo

Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can be countered by optimizing the osteointegration capacity of...

Descripción completa

Detalles Bibliográficos
Autores principales: Stich, Theresia, Alagboso, Francisca, Křenek, Tomáš, Kovářík, Tomáš, Alt, Volker, Docheva, Denitsa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780039/
https://www.ncbi.nlm.nih.gov/pubmed/35079626
http://dx.doi.org/10.1002/btm2.10239
_version_ 1784637731373056000
author Stich, Theresia
Alagboso, Francisca
Křenek, Tomáš
Kovářík, Tomáš
Alt, Volker
Docheva, Denitsa
author_facet Stich, Theresia
Alagboso, Francisca
Křenek, Tomáš
Kovářík, Tomáš
Alt, Volker
Docheva, Denitsa
author_sort Stich, Theresia
collection PubMed
description Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can be countered by optimizing the osteointegration capacity of implant materials. Implant surface modifications for structuring, roughening and biological activation in favor for osteogenic differentiation have been vastly studied. A key factor for a successful stable long‐term integration is the initial cellular response to the implant material. Hence, cell–material interactions, which are dependent on the surface parameters, need to be considered in the implant design. Therefore, this review starts with an introduction to the basics of cell–material interactions as well as common surface modification techniques. Afterwards, recent research on the impact of osteogenic processes in vitro and vivo provoked by various surface modifications is reviewed and discussed, in order to give an update on currently applied and developing implant modification techniques for enhancing osteointegration.
format Online
Article
Text
id pubmed-8780039
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley & Sons, Inc.
record_format MEDLINE/PubMed
spelling pubmed-87800392022-01-24 Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo Stich, Theresia Alagboso, Francisca Křenek, Tomáš Kovářík, Tomáš Alt, Volker Docheva, Denitsa Bioeng Transl Med Reviews Titanium is commonly and successfully used in dental and orthopedic implants. However, patients still have to face the risk of implant failure due to various reasons, such as implant loosening or infection. The risk of implant loosening can be countered by optimizing the osteointegration capacity of implant materials. Implant surface modifications for structuring, roughening and biological activation in favor for osteogenic differentiation have been vastly studied. A key factor for a successful stable long‐term integration is the initial cellular response to the implant material. Hence, cell–material interactions, which are dependent on the surface parameters, need to be considered in the implant design. Therefore, this review starts with an introduction to the basics of cell–material interactions as well as common surface modification techniques. Afterwards, recent research on the impact of osteogenic processes in vitro and vivo provoked by various surface modifications is reviewed and discussed, in order to give an update on currently applied and developing implant modification techniques for enhancing osteointegration. John Wiley & Sons, Inc. 2021-07-12 /pmc/articles/PMC8780039/ /pubmed/35079626 http://dx.doi.org/10.1002/btm2.10239 Text en © 2021 The Authors. Bioengineering & Translational Medicine published by Wiley Periodicals LLC on behalf of American Institute of Chemical Engineers. https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Stich, Theresia
Alagboso, Francisca
Křenek, Tomáš
Kovářík, Tomáš
Alt, Volker
Docheva, Denitsa
Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title_full Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title_fullStr Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title_full_unstemmed Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title_short Implant‐bone‐interface: Reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
title_sort implant‐bone‐interface: reviewing the impact of titanium surface modifications on osteogenic processes in vitro and in vivo
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780039/
https://www.ncbi.nlm.nih.gov/pubmed/35079626
http://dx.doi.org/10.1002/btm2.10239
work_keys_str_mv AT stichtheresia implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo
AT alagbosofrancisca implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo
AT krenektomas implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo
AT kovariktomas implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo
AT altvolker implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo
AT dochevadenitsa implantboneinterfacereviewingtheimpactoftitaniumsurfacemodificationsonosteogenicprocessesinvitroandinvivo