Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells

Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages,...

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Detalles Bibliográficos
Autores principales: Jang, Sunhee, Kwon, Eui-Jong, Lee, Jennifer Jooha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780115/
https://www.ncbi.nlm.nih.gov/pubmed/35055087
http://dx.doi.org/10.3390/ijms23020905
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author Jang, Sunhee
Kwon, Eui-Jong
Lee, Jennifer Jooha
author_facet Jang, Sunhee
Kwon, Eui-Jong
Lee, Jennifer Jooha
author_sort Jang, Sunhee
collection PubMed
description Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets.
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spelling pubmed-87801152022-01-22 Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells Jang, Sunhee Kwon, Eui-Jong Lee, Jennifer Jooha Int J Mol Sci Review Rheumatoid arthritis (RA) is a chronic, systemic autoimmune disease associated with synovial tissue proliferation, pannus formation, cartilage destruction, and systemic complications. Currently, advanced understandings of the pathologic mechanisms of autoreactive CD4+ T cells, B cells, macrophages, inflammatory cytokines, chemokines, and autoantibodies that cause RA have been achieved, despite the fact that much remains to be elucidated. This review provides an updated pathogenesis of RA which will unveil novel therapeutic targets. MDPI 2022-01-14 /pmc/articles/PMC8780115/ /pubmed/35055087 http://dx.doi.org/10.3390/ijms23020905 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Jang, Sunhee
Kwon, Eui-Jong
Lee, Jennifer Jooha
Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title_full Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title_fullStr Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title_full_unstemmed Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title_short Rheumatoid Arthritis: Pathogenic Roles of Diverse Immune Cells
title_sort rheumatoid arthritis: pathogenic roles of diverse immune cells
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780115/
https://www.ncbi.nlm.nih.gov/pubmed/35055087
http://dx.doi.org/10.3390/ijms23020905
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AT kwoneuijong rheumatoidarthritispathogenicrolesofdiverseimmunecells
AT leejenniferjooha rheumatoidarthritispathogenicrolesofdiverseimmunecells

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