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Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration

Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the f...

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Autores principales: Lains, Ines, Mendez, Kevin, Nigalye, Archana, Katz, Raviv, Douglas, Vivian Paraskevi, Kelly, Rachel S., Kim, Ivana K., Miller, John B., Vavvas, Demetrios G., Liang, Liming, Lasky-Su, Jessica, Miller, Joan W., Husain, Deeba
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780121/
https://www.ncbi.nlm.nih.gov/pubmed/35050154
http://dx.doi.org/10.3390/metabo12010032
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author Lains, Ines
Mendez, Kevin
Nigalye, Archana
Katz, Raviv
Douglas, Vivian Paraskevi
Kelly, Rachel S.
Kim, Ivana K.
Miller, John B.
Vavvas, Demetrios G.
Liang, Liming
Lasky-Su, Jessica
Miller, Joan W.
Husain, Deeba
author_facet Lains, Ines
Mendez, Kevin
Nigalye, Archana
Katz, Raviv
Douglas, Vivian Paraskevi
Kelly, Rachel S.
Kim, Ivana K.
Miller, John B.
Vavvas, Demetrios G.
Liang, Liming
Lasky-Su, Jessica
Miller, Joan W.
Husain, Deeba
author_sort Lains, Ines
collection PubMed
description Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the first time, the association between plasma metabolomic profiles and progression of AMD over a 3-year period. At baseline and 3 years later, subjects with AMD (n = 108 eyes) and controls (n = 45 eyes) were imaged with color fundus photos for AMD staging and tested for retinal function with dark adaptation (DA). Fasting plasma samples were also collected for metabolomic profiling. AMD progression was considered present if AMD stage at 3 years was more advanced than at baseline (n = 26 eyes, 17%). Results showed that, of the metabolites measured at baseline, eight were associated with 3-year AMD progression (p < 0.01) and 19 (p < 0.01) with changes in DA. Additionally, changes in the levels (i.e., between 3 years and baseline) of 6 and 17 metabolites demonstrated significant associations (p < 0.01) with AMD progression and DA, respectively. In conclusion, plasma metabolomic profiles are associated with clinical and functional progression of AMD at 3 years. These findings contribute to our understanding of mechanisms of AMD progression and the identification of potential therapeutics for this blinding disease.
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spelling pubmed-87801212022-01-22 Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration Lains, Ines Mendez, Kevin Nigalye, Archana Katz, Raviv Douglas, Vivian Paraskevi Kelly, Rachel S. Kim, Ivana K. Miller, John B. Vavvas, Demetrios G. Liang, Liming Lasky-Su, Jessica Miller, Joan W. Husain, Deeba Metabolites Article Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the first time, the association between plasma metabolomic profiles and progression of AMD over a 3-year period. At baseline and 3 years later, subjects with AMD (n = 108 eyes) and controls (n = 45 eyes) were imaged with color fundus photos for AMD staging and tested for retinal function with dark adaptation (DA). Fasting plasma samples were also collected for metabolomic profiling. AMD progression was considered present if AMD stage at 3 years was more advanced than at baseline (n = 26 eyes, 17%). Results showed that, of the metabolites measured at baseline, eight were associated with 3-year AMD progression (p < 0.01) and 19 (p < 0.01) with changes in DA. Additionally, changes in the levels (i.e., between 3 years and baseline) of 6 and 17 metabolites demonstrated significant associations (p < 0.01) with AMD progression and DA, respectively. In conclusion, plasma metabolomic profiles are associated with clinical and functional progression of AMD at 3 years. These findings contribute to our understanding of mechanisms of AMD progression and the identification of potential therapeutics for this blinding disease. MDPI 2022-01-01 /pmc/articles/PMC8780121/ /pubmed/35050154 http://dx.doi.org/10.3390/metabo12010032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lains, Ines
Mendez, Kevin
Nigalye, Archana
Katz, Raviv
Douglas, Vivian Paraskevi
Kelly, Rachel S.
Kim, Ivana K.
Miller, John B.
Vavvas, Demetrios G.
Liang, Liming
Lasky-Su, Jessica
Miller, Joan W.
Husain, Deeba
Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title_full Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title_fullStr Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title_full_unstemmed Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title_short Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
title_sort plasma metabolomic profiles associated with three-year progression of age-related macular degeneration
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780121/
https://www.ncbi.nlm.nih.gov/pubmed/35050154
http://dx.doi.org/10.3390/metabo12010032
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