Cargando…
Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration
Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the f...
Autores principales: | , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780121/ https://www.ncbi.nlm.nih.gov/pubmed/35050154 http://dx.doi.org/10.3390/metabo12010032 |
_version_ | 1784637754026491904 |
---|---|
author | Lains, Ines Mendez, Kevin Nigalye, Archana Katz, Raviv Douglas, Vivian Paraskevi Kelly, Rachel S. Kim, Ivana K. Miller, John B. Vavvas, Demetrios G. Liang, Liming Lasky-Su, Jessica Miller, Joan W. Husain, Deeba |
author_facet | Lains, Ines Mendez, Kevin Nigalye, Archana Katz, Raviv Douglas, Vivian Paraskevi Kelly, Rachel S. Kim, Ivana K. Miller, John B. Vavvas, Demetrios G. Liang, Liming Lasky-Su, Jessica Miller, Joan W. Husain, Deeba |
author_sort | Lains, Ines |
collection | PubMed |
description | Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the first time, the association between plasma metabolomic profiles and progression of AMD over a 3-year period. At baseline and 3 years later, subjects with AMD (n = 108 eyes) and controls (n = 45 eyes) were imaged with color fundus photos for AMD staging and tested for retinal function with dark adaptation (DA). Fasting plasma samples were also collected for metabolomic profiling. AMD progression was considered present if AMD stage at 3 years was more advanced than at baseline (n = 26 eyes, 17%). Results showed that, of the metabolites measured at baseline, eight were associated with 3-year AMD progression (p < 0.01) and 19 (p < 0.01) with changes in DA. Additionally, changes in the levels (i.e., between 3 years and baseline) of 6 and 17 metabolites demonstrated significant associations (p < 0.01) with AMD progression and DA, respectively. In conclusion, plasma metabolomic profiles are associated with clinical and functional progression of AMD at 3 years. These findings contribute to our understanding of mechanisms of AMD progression and the identification of potential therapeutics for this blinding disease. |
format | Online Article Text |
id | pubmed-8780121 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87801212022-01-22 Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration Lains, Ines Mendez, Kevin Nigalye, Archana Katz, Raviv Douglas, Vivian Paraskevi Kelly, Rachel S. Kim, Ivana K. Miller, John B. Vavvas, Demetrios G. Liang, Liming Lasky-Su, Jessica Miller, Joan W. Husain, Deeba Metabolites Article Plasma metabolomic profiles have been shown to be associated with age-related macular degeneration (AMD) and its severity stages. However, all studies performed to date have been cross-sectional and have not assessed progression of AMD. This prospective, longitudinal, pilot study analyzes, for the first time, the association between plasma metabolomic profiles and progression of AMD over a 3-year period. At baseline and 3 years later, subjects with AMD (n = 108 eyes) and controls (n = 45 eyes) were imaged with color fundus photos for AMD staging and tested for retinal function with dark adaptation (DA). Fasting plasma samples were also collected for metabolomic profiling. AMD progression was considered present if AMD stage at 3 years was more advanced than at baseline (n = 26 eyes, 17%). Results showed that, of the metabolites measured at baseline, eight were associated with 3-year AMD progression (p < 0.01) and 19 (p < 0.01) with changes in DA. Additionally, changes in the levels (i.e., between 3 years and baseline) of 6 and 17 metabolites demonstrated significant associations (p < 0.01) with AMD progression and DA, respectively. In conclusion, plasma metabolomic profiles are associated with clinical and functional progression of AMD at 3 years. These findings contribute to our understanding of mechanisms of AMD progression and the identification of potential therapeutics for this blinding disease. MDPI 2022-01-01 /pmc/articles/PMC8780121/ /pubmed/35050154 http://dx.doi.org/10.3390/metabo12010032 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Lains, Ines Mendez, Kevin Nigalye, Archana Katz, Raviv Douglas, Vivian Paraskevi Kelly, Rachel S. Kim, Ivana K. Miller, John B. Vavvas, Demetrios G. Liang, Liming Lasky-Su, Jessica Miller, Joan W. Husain, Deeba Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title | Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title_full | Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title_fullStr | Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title_full_unstemmed | Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title_short | Plasma Metabolomic Profiles Associated with Three-Year Progression of Age-Related Macular Degeneration |
title_sort | plasma metabolomic profiles associated with three-year progression of age-related macular degeneration |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780121/ https://www.ncbi.nlm.nih.gov/pubmed/35050154 http://dx.doi.org/10.3390/metabo12010032 |
work_keys_str_mv | AT lainsines plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT mendezkevin plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT nigalyearchana plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT katzraviv plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT douglasvivianparaskevi plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT kellyrachels plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT kimivanak plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT millerjohnb plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT vavvasdemetriosg plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT liangliming plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT laskysujessica plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT millerjoanw plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration AT husaindeeba plasmametabolomicprofilesassociatedwiththreeyearprogressionofagerelatedmaculardegeneration |