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Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality

Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by pregnant women; however, they have been associated with adverse pregnancy outcomes and perinatal morbidity in pregnant women and animal models. We investigated the effects of two SSRI, fluoxetine and sertraline...

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Autores principales: Domingues, Rafael R., Fricke, Hannah P., Sheftel, Celeste M., Bell, Autumn M., Sartori, Luma C., Manuel, Robbie S. J., Krajco, Chandler J., Wiltbank, Milo C., Hernandez, Laura L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780128/
https://www.ncbi.nlm.nih.gov/pubmed/35051053
http://dx.doi.org/10.3390/toxics10010011
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author Domingues, Rafael R.
Fricke, Hannah P.
Sheftel, Celeste M.
Bell, Autumn M.
Sartori, Luma C.
Manuel, Robbie S. J.
Krajco, Chandler J.
Wiltbank, Milo C.
Hernandez, Laura L.
author_facet Domingues, Rafael R.
Fricke, Hannah P.
Sheftel, Celeste M.
Bell, Autumn M.
Sartori, Luma C.
Manuel, Robbie S. J.
Krajco, Chandler J.
Wiltbank, Milo C.
Hernandez, Laura L.
author_sort Domingues, Rafael R.
collection PubMed
description Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by pregnant women; however, they have been associated with adverse pregnancy outcomes and perinatal morbidity in pregnant women and animal models. We investigated the effects of two SSRI, fluoxetine and sertraline, on pregnancy and neonatal outcomes in mice. Wild-type mice were treated daily with low and high doses of fluoxetine (2 and 20 mg/kg) and sertraline (10 and 20 mg/kg) from the day of detection of a vaginal plug until the end of lactation (21 days postpartum). Pregnancy rate was decreased only in the high dose of fluoxetine group. Maternal weight gain was reduced in the groups receiving the high dose of each drug. Number of pups born was decreased in the high dose of fluoxetine and low and high doses of sertraline while the number of pups weaned was decreased in all SSRI-treated groups corresponding to increased neonatal mortality in all SSRI-treated groups. In conclusion, there was a dose-dependent effect of SSRI on pregnancy and neonatal outcomes in a non-depressed mouse model. However, the distinct placental transfer of each drug suggests that the effects of SSRI on pup mortality may be mediated by SSRI-induced placental insufficiency rather than a direct toxic effect on neonatal development and mortality.
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spelling pubmed-87801282022-01-22 Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality Domingues, Rafael R. Fricke, Hannah P. Sheftel, Celeste M. Bell, Autumn M. Sartori, Luma C. Manuel, Robbie S. J. Krajco, Chandler J. Wiltbank, Milo C. Hernandez, Laura L. Toxics Article Selective serotonin reuptake inhibitors (SSRI) are the most common antidepressant used by pregnant women; however, they have been associated with adverse pregnancy outcomes and perinatal morbidity in pregnant women and animal models. We investigated the effects of two SSRI, fluoxetine and sertraline, on pregnancy and neonatal outcomes in mice. Wild-type mice were treated daily with low and high doses of fluoxetine (2 and 20 mg/kg) and sertraline (10 and 20 mg/kg) from the day of detection of a vaginal plug until the end of lactation (21 days postpartum). Pregnancy rate was decreased only in the high dose of fluoxetine group. Maternal weight gain was reduced in the groups receiving the high dose of each drug. Number of pups born was decreased in the high dose of fluoxetine and low and high doses of sertraline while the number of pups weaned was decreased in all SSRI-treated groups corresponding to increased neonatal mortality in all SSRI-treated groups. In conclusion, there was a dose-dependent effect of SSRI on pregnancy and neonatal outcomes in a non-depressed mouse model. However, the distinct placental transfer of each drug suggests that the effects of SSRI on pup mortality may be mediated by SSRI-induced placental insufficiency rather than a direct toxic effect on neonatal development and mortality. MDPI 2022-01-01 /pmc/articles/PMC8780128/ /pubmed/35051053 http://dx.doi.org/10.3390/toxics10010011 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Domingues, Rafael R.
Fricke, Hannah P.
Sheftel, Celeste M.
Bell, Autumn M.
Sartori, Luma C.
Manuel, Robbie S. J.
Krajco, Chandler J.
Wiltbank, Milo C.
Hernandez, Laura L.
Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title_full Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title_fullStr Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title_full_unstemmed Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title_short Effect of Low and High Doses of Two Selective Serotonin Reuptake Inhibitors on Pregnancy Outcomes and Neonatal Mortality
title_sort effect of low and high doses of two selective serotonin reuptake inhibitors on pregnancy outcomes and neonatal mortality
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780128/
https://www.ncbi.nlm.nih.gov/pubmed/35051053
http://dx.doi.org/10.3390/toxics10010011
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