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Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy

Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflam...

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Autores principales: Chen, Shuang, Xu, Da, Fan, Liu, Fang, Zhi, Wang, Xiufeng, Li, Man
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780133/
https://www.ncbi.nlm.nih.gov/pubmed/35069111
http://dx.doi.org/10.3389/fnmol.2021.797253
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author Chen, Shuang
Xu, Da
Fan, Liu
Fang, Zhi
Wang, Xiufeng
Li, Man
author_facet Chen, Shuang
Xu, Da
Fan, Liu
Fang, Zhi
Wang, Xiufeng
Li, Man
author_sort Chen, Shuang
collection PubMed
description Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies.
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spelling pubmed-87801332022-01-22 Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy Chen, Shuang Xu, Da Fan, Liu Fang, Zhi Wang, Xiufeng Li, Man Front Mol Neurosci Molecular Neuroscience Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal discharges, nerve conduction, neuron injury and inflammation, thereby they may participate in epileptogenesis. NMDARs belong to a family of ionotropic glutamate receptors that play essential roles in excitatory neurotransmission and synaptic plasticity in the mammalian CNS. Despite numerous studies focusing on the role of NMDAR in epilepsy, the relationship appeared to be elusive. In this article, we reviewed the regulation of NMDAR and possible mechanisms of NMDAR in epilepsy and in respect of onset, development, and treatment, trying to provide more evidence for future studies. Frontiers Media S.A. 2022-01-07 /pmc/articles/PMC8780133/ /pubmed/35069111 http://dx.doi.org/10.3389/fnmol.2021.797253 Text en Copyright © 2022 Chen, Xu, Fan, Fang, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Chen, Shuang
Xu, Da
Fan, Liu
Fang, Zhi
Wang, Xiufeng
Li, Man
Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title_full Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title_fullStr Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title_full_unstemmed Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title_short Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy
title_sort roles of n-methyl-d-aspartate receptors (nmdars) in epilepsy
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780133/
https://www.ncbi.nlm.nih.gov/pubmed/35069111
http://dx.doi.org/10.3389/fnmol.2021.797253
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