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Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780193/ https://www.ncbi.nlm.nih.gov/pubmed/35057546 http://dx.doi.org/10.3390/nu14020365 |
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author | Issa, Amy Edwards, Jensen Singh, Meenal Friesen, Craig Edwards, Sarah |
author_facet | Issa, Amy Edwards, Jensen Singh, Meenal Friesen, Craig Edwards, Sarah |
author_sort | Issa, Amy |
collection | PubMed |
description | Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density of EGD biopsies in pediatric patients with symptoms of decreased volume or variety of ingested foods. Methods: We conducted a single-center, retrospective chart review of EMRs for all new feeding clinic patients between 0 and 17 years of age. Patients were categorized by symptoms at the initial visit as well as eosinophil and mast cell densities in those with EGD biopsies. Ten patients were identified as controls. Results: We identified 30 patients each with volume and variety limitation. Antral mast cell density was increased in 32.1% of variety-limited patients, 37.5% of volume limited patients, and in no controls; Duodenal mast cell density was increased in 32.1% of variety-limited patients, 40.6% of volume-limited patients, and in no controls. Conclusions: In both variety- and volume-limited patients, antral and duodenal mast cell densities were increased. These associations warrant further investigation of the mechanism between mast cells and development of feeding difficulties, allowing more targeted pediatric therapies. |
format | Online Article Text |
id | pubmed-8780193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87801932022-01-22 Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake Issa, Amy Edwards, Jensen Singh, Meenal Friesen, Craig Edwards, Sarah Nutrients Article Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density of EGD biopsies in pediatric patients with symptoms of decreased volume or variety of ingested foods. Methods: We conducted a single-center, retrospective chart review of EMRs for all new feeding clinic patients between 0 and 17 years of age. Patients were categorized by symptoms at the initial visit as well as eosinophil and mast cell densities in those with EGD biopsies. Ten patients were identified as controls. Results: We identified 30 patients each with volume and variety limitation. Antral mast cell density was increased in 32.1% of variety-limited patients, 37.5% of volume limited patients, and in no controls; Duodenal mast cell density was increased in 32.1% of variety-limited patients, 40.6% of volume-limited patients, and in no controls. Conclusions: In both variety- and volume-limited patients, antral and duodenal mast cell densities were increased. These associations warrant further investigation of the mechanism between mast cells and development of feeding difficulties, allowing more targeted pediatric therapies. MDPI 2022-01-15 /pmc/articles/PMC8780193/ /pubmed/35057546 http://dx.doi.org/10.3390/nu14020365 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Issa, Amy Edwards, Jensen Singh, Meenal Friesen, Craig Edwards, Sarah Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title | Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title_full | Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title_fullStr | Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title_full_unstemmed | Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title_short | Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake |
title_sort | presence of increased mast cells in infants and children with volume and variety limited intake |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780193/ https://www.ncbi.nlm.nih.gov/pubmed/35057546 http://dx.doi.org/10.3390/nu14020365 |
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