Cargando…

Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake

Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density...

Descripción completa

Detalles Bibliográficos
Autores principales: Issa, Amy, Edwards, Jensen, Singh, Meenal, Friesen, Craig, Edwards, Sarah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780193/
https://www.ncbi.nlm.nih.gov/pubmed/35057546
http://dx.doi.org/10.3390/nu14020365
_version_ 1784637777086775296
author Issa, Amy
Edwards, Jensen
Singh, Meenal
Friesen, Craig
Edwards, Sarah
author_facet Issa, Amy
Edwards, Jensen
Singh, Meenal
Friesen, Craig
Edwards, Sarah
author_sort Issa, Amy
collection PubMed
description Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density of EGD biopsies in pediatric patients with symptoms of decreased volume or variety of ingested foods. Methods: We conducted a single-center, retrospective chart review of EMRs for all new feeding clinic patients between 0 and 17 years of age. Patients were categorized by symptoms at the initial visit as well as eosinophil and mast cell densities in those with EGD biopsies. Ten patients were identified as controls. Results: We identified 30 patients each with volume and variety limitation. Antral mast cell density was increased in 32.1% of variety-limited patients, 37.5% of volume limited patients, and in no controls; Duodenal mast cell density was increased in 32.1% of variety-limited patients, 40.6% of volume-limited patients, and in no controls. Conclusions: In both variety- and volume-limited patients, antral and duodenal mast cell densities were increased. These associations warrant further investigation of the mechanism between mast cells and development of feeding difficulties, allowing more targeted pediatric therapies.
format Online
Article
Text
id pubmed-8780193
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-87801932022-01-22 Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake Issa, Amy Edwards, Jensen Singh, Meenal Friesen, Craig Edwards, Sarah Nutrients Article Background: Reports indicate patients with feeding difficulties demonstrate signs of inflammation on biopsies, notably eosinophilia, but it is unknown whether mast cell density contributes to variety or volume limitation symptoms. The aim of our study was to evaluate eosinophil and mast cell density of EGD biopsies in pediatric patients with symptoms of decreased volume or variety of ingested foods. Methods: We conducted a single-center, retrospective chart review of EMRs for all new feeding clinic patients between 0 and 17 years of age. Patients were categorized by symptoms at the initial visit as well as eosinophil and mast cell densities in those with EGD biopsies. Ten patients were identified as controls. Results: We identified 30 patients each with volume and variety limitation. Antral mast cell density was increased in 32.1% of variety-limited patients, 37.5% of volume limited patients, and in no controls; Duodenal mast cell density was increased in 32.1% of variety-limited patients, 40.6% of volume-limited patients, and in no controls. Conclusions: In both variety- and volume-limited patients, antral and duodenal mast cell densities were increased. These associations warrant further investigation of the mechanism between mast cells and development of feeding difficulties, allowing more targeted pediatric therapies. MDPI 2022-01-15 /pmc/articles/PMC8780193/ /pubmed/35057546 http://dx.doi.org/10.3390/nu14020365 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Issa, Amy
Edwards, Jensen
Singh, Meenal
Friesen, Craig
Edwards, Sarah
Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title_full Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title_fullStr Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title_full_unstemmed Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title_short Presence of Increased Mast Cells in Infants and Children with Volume and Variety Limited Intake
title_sort presence of increased mast cells in infants and children with volume and variety limited intake
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780193/
https://www.ncbi.nlm.nih.gov/pubmed/35057546
http://dx.doi.org/10.3390/nu14020365
work_keys_str_mv AT issaamy presenceofincreasedmastcellsininfantsandchildrenwithvolumeandvarietylimitedintake
AT edwardsjensen presenceofincreasedmastcellsininfantsandchildrenwithvolumeandvarietylimitedintake
AT singhmeenal presenceofincreasedmastcellsininfantsandchildrenwithvolumeandvarietylimitedintake
AT friesencraig presenceofincreasedmastcellsininfantsandchildrenwithvolumeandvarietylimitedintake
AT edwardssarah presenceofincreasedmastcellsininfantsandchildrenwithvolumeandvarietylimitedintake