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Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia

Studies reported an association between impaired hearing and vestibular function with the risk of dementia. This study investigated the association between Ménière’s disease (MD) and the risk of dementia using a nationwide cohort sample of data obtained from the South Korea National Health Insurance...

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Autores principales: Lee, Il Hwan, Yu, Hyunjae, Ha, Seung-Su, Son, Gil Myeong, Park, Ki Joon, Lee, Jae Jun, Kim, Dong-Kyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780200/
https://www.ncbi.nlm.nih.gov/pubmed/35055334
http://dx.doi.org/10.3390/jpm12010019
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author Lee, Il Hwan
Yu, Hyunjae
Ha, Seung-Su
Son, Gil Myeong
Park, Ki Joon
Lee, Jae Jun
Kim, Dong-Kyu
author_facet Lee, Il Hwan
Yu, Hyunjae
Ha, Seung-Su
Son, Gil Myeong
Park, Ki Joon
Lee, Jae Jun
Kim, Dong-Kyu
author_sort Lee, Il Hwan
collection PubMed
description Studies reported an association between impaired hearing and vestibular function with the risk of dementia. This study investigated the association between Ménière’s disease (MD) and the risk of dementia using a nationwide cohort sample of data obtained from the South Korea National Health Insurance Service. The MD group (n = 496) included patients aged over 55 years and diagnosed between 2003 and 2006. The comparison group was selected using propensity score matching (n = 1984). Cox proportional hazards regression models were used to calculate incidence and hazard ratios for dementia events. The incidence of dementia was 14.3 per 1000 person–years in the MD group. After adjustment for certain variables, the incidence of dementia was higher in the MD group than in the comparison group (adjusted hazard ratio (HR) = 1.57, 95% confidence interval = 1.17–2.12). Subgroup analysis showed a significantly increased adjusted HR for developing Alzheimer’s disease (1.69, 95% confidence interval = 1.20–2.37) and vascular dementia (1.99, 95% confidence interval = 1.10–3.57) in the MD group. Patients with dementia experienced a higher frequency of MD episodes than those without dementia. Our findings suggest that late-onset MD is associated with an increased incidence of all-cause dementia, and it might be used as a basis for an earlier diagnosis of dementia.
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spelling pubmed-87802002022-01-22 Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia Lee, Il Hwan Yu, Hyunjae Ha, Seung-Su Son, Gil Myeong Park, Ki Joon Lee, Jae Jun Kim, Dong-Kyu J Pers Med Article Studies reported an association between impaired hearing and vestibular function with the risk of dementia. This study investigated the association between Ménière’s disease (MD) and the risk of dementia using a nationwide cohort sample of data obtained from the South Korea National Health Insurance Service. The MD group (n = 496) included patients aged over 55 years and diagnosed between 2003 and 2006. The comparison group was selected using propensity score matching (n = 1984). Cox proportional hazards regression models were used to calculate incidence and hazard ratios for dementia events. The incidence of dementia was 14.3 per 1000 person–years in the MD group. After adjustment for certain variables, the incidence of dementia was higher in the MD group than in the comparison group (adjusted hazard ratio (HR) = 1.57, 95% confidence interval = 1.17–2.12). Subgroup analysis showed a significantly increased adjusted HR for developing Alzheimer’s disease (1.69, 95% confidence interval = 1.20–2.37) and vascular dementia (1.99, 95% confidence interval = 1.10–3.57) in the MD group. Patients with dementia experienced a higher frequency of MD episodes than those without dementia. Our findings suggest that late-onset MD is associated with an increased incidence of all-cause dementia, and it might be used as a basis for an earlier diagnosis of dementia. MDPI 2021-12-31 /pmc/articles/PMC8780200/ /pubmed/35055334 http://dx.doi.org/10.3390/jpm12010019 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Lee, Il Hwan
Yu, Hyunjae
Ha, Seung-Su
Son, Gil Myeong
Park, Ki Joon
Lee, Jae Jun
Kim, Dong-Kyu
Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title_full Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title_fullStr Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title_full_unstemmed Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title_short Association between Late-Onset Ménière’s Disease and the Risk of Incident All-Cause Dementia
title_sort association between late-onset ménière’s disease and the risk of incident all-cause dementia
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780200/
https://www.ncbi.nlm.nih.gov/pubmed/35055334
http://dx.doi.org/10.3390/jpm12010019
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