BCR-ABL1 Tyrosine Kinase Complex Signaling Transduction: Challenges to Overcome Resistance in Chronic Myeloid Leukemia

The constitutively active BCR-ABL1 tyrosine kinase, found in t(9;22)(q34;q11) chromosomal translocation-derived leukemia, initiates an extremely complex signaling transduction cascade that induces a strong state of resistance to chemotherapy. Targeted therapies based on tyrosine kinase inhibitors (T...

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Detalles Bibliográficos
Autores principales: Amarante-Mendes, Gustavo P., Rana, Aamir, Datoguia, Tarcila Santos, Hamerschlak, Nelson, Brumatti, Gabriela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780254/
https://www.ncbi.nlm.nih.gov/pubmed/35057108
http://dx.doi.org/10.3390/pharmaceutics14010215

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