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Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO

BACKGROUND: To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). METHODS: The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSER...

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Autores principales: Llop, Maria, Moreno, Mireia, Navarro-Compán, Victoria, Juanola, Xavier, de Miguel, Eugenio, Almodóvar, Raquel, Quintana, Eduardo Cuende, Sanz, Jesús Sanz, Beltrán, Emma, Montesinos, M. Dolores Ruiz, Calvet, Joan, Berenguer-Llergo, Antoni, Gratacós, Jordi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780330/
https://www.ncbi.nlm.nih.gov/pubmed/35063018
http://dx.doi.org/10.1186/s13075-021-02695-5
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author Llop, Maria
Moreno, Mireia
Navarro-Compán, Victoria
Juanola, Xavier
de Miguel, Eugenio
Almodóvar, Raquel
Quintana, Eduardo Cuende
Sanz, Jesús Sanz
Beltrán, Emma
Montesinos, M. Dolores Ruiz
Calvet, Joan
Berenguer-Llergo, Antoni
Gratacós, Jordi
author_facet Llop, Maria
Moreno, Mireia
Navarro-Compán, Victoria
Juanola, Xavier
de Miguel, Eugenio
Almodóvar, Raquel
Quintana, Eduardo Cuende
Sanz, Jesús Sanz
Beltrán, Emma
Montesinos, M. Dolores Ruiz
Calvet, Joan
Berenguer-Llergo, Antoni
Gratacós, Jordi
author_sort Llop, Maria
collection PubMed
description BACKGROUND: To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). METHODS: The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (≥4 years) and (ii) no long-term treatment (< 4 years). Radiographs were scored by two readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with known chronology. Disease activity differences between patients’ groups at each time point were assessed using a linear mixed-effect model. RESULTS: Radiographic progression was defined as an increase in ≥2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (≥4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). CONCLUSIONS: Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02695-5.
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spelling pubmed-87803302022-01-21 Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO Llop, Maria Moreno, Mireia Navarro-Compán, Victoria Juanola, Xavier de Miguel, Eugenio Almodóvar, Raquel Quintana, Eduardo Cuende Sanz, Jesús Sanz Beltrán, Emma Montesinos, M. Dolores Ruiz Calvet, Joan Berenguer-Llergo, Antoni Gratacós, Jordi Arthritis Res Ther Research Article BACKGROUND: To evaluate the influence of the disease activity on radiographic progression in axial spondyloarthritis (axSpA) patients treated with TNF inhibitors (TNFi). METHODS: The study included 101 axSpA patients from the Spanish Register of Biological Therapy in Spondyloarthritides (REGISPONSERBIO), which had clinical data and radiographic assessment available. Patients were classified into 2 groups based on the duration of TNFi treatment at baseline: (i) long-term treatment (≥4 years) and (ii) no long-term treatment (< 4 years). Radiographs were scored by two readers according to the modified Stoke Ankylosing Spondylitis Spine Score (mSASSS) with known chronology. Disease activity differences between patients’ groups at each time point were assessed using a linear mixed-effect model. RESULTS: Radiographic progression was defined as an increase in ≥2 mSASSS units. At inclusion, approximately half of the patients (45.5%) were receiving long-term treatment with TNFi (≥4 years). In this group of subjects, a significant difference in averaged Ankylosing Spondylitis disease Activity Score (ASDAS) across follow-up was found between progressors and non-progressors (2.33 vs 1.76, p=0.027, respectively). In patients not under long-term TNFi treatment (54.5%) though, no significant ASDAS differences were observed between progressors and non-progressors until the third year of follow-up. Furthermore, no significant differences were found in progression status, when disease activity was measured by Bath Ankylosing spondylitis Disease Activity Index (BASDAI) and C reactive protein (CRP). CONCLUSIONS: Patients on long-term TNFi treatment with a mean sustained low disease activity measures by ASDAS presented lower radiographic progression than those with active disease. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13075-021-02695-5. BioMed Central 2022-01-21 2022 /pmc/articles/PMC8780330/ /pubmed/35063018 http://dx.doi.org/10.1186/s13075-021-02695-5 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Llop, Maria
Moreno, Mireia
Navarro-Compán, Victoria
Juanola, Xavier
de Miguel, Eugenio
Almodóvar, Raquel
Quintana, Eduardo Cuende
Sanz, Jesús Sanz
Beltrán, Emma
Montesinos, M. Dolores Ruiz
Calvet, Joan
Berenguer-Llergo, Antoni
Gratacós, Jordi
Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title_full Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title_fullStr Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title_full_unstemmed Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title_short Sustained low disease activity measured by ASDAS slow radiographic spinal progression in axial spondyloarthritis patients treated with TNF-inhibitors: data from REGISPONSERBIO
title_sort sustained low disease activity measured by asdas slow radiographic spinal progression in axial spondyloarthritis patients treated with tnf-inhibitors: data from regisponserbio
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780330/
https://www.ncbi.nlm.nih.gov/pubmed/35063018
http://dx.doi.org/10.1186/s13075-021-02695-5
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