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Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants
Natural compounds have historically had a wide application in nutrition. Recently, a fundamental role has been identified for essential oils extracted from aromatic plants for their nutritional, antimicrobial, and antioxidant properties, and as food preservatives. In the present study, essential oil...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780331/ https://www.ncbi.nlm.nih.gov/pubmed/35057572 http://dx.doi.org/10.3390/nu14020391 |
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author | D’Aquila, Patrizia Paparazzo, Ersilia Crudo, Michele Bonacci, Sonia Procopio, Antonio Passarino, Giuseppe Bellizzi, Dina |
author_facet | D’Aquila, Patrizia Paparazzo, Ersilia Crudo, Michele Bonacci, Sonia Procopio, Antonio Passarino, Giuseppe Bellizzi, Dina |
author_sort | D’Aquila, Patrizia |
collection | PubMed |
description | Natural compounds have historically had a wide application in nutrition. Recently, a fundamental role has been identified for essential oils extracted from aromatic plants for their nutritional, antimicrobial, and antioxidant properties, and as food preservatives. In the present study, essential oils (EOs) from ten aromatic plants grown in Calabria (Italy), used routinely to impart aroma and taste to food, were evaluated for their antibacterial activity. This activity was investigated against Escherichia coli strain JM109, and its derived antibiotic-resistant cells selected by growing the strain at low concentrations of ampicillin, ciprofloxacin, and gentamicin by measuring the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Although all the essential oils showed bactericidal activity, those from Clinopodium nepeta, Origanum vulgare, and Foeniculum vulgare displayed the greatest inhibitory effects on the bacterial growth of all cell lines. It is plausible that the antibacterial activity is mediated by epigenetic modifications since the tested essential oils induce methylation both at adenine and cytosine residues in the genomes of most cell lines. This study contributes to a further characterization of the properties of essential oils by shedding new light on the molecular mechanisms that mediate these properties. |
format | Online Article Text |
id | pubmed-8780331 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-87803312022-01-22 Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants D’Aquila, Patrizia Paparazzo, Ersilia Crudo, Michele Bonacci, Sonia Procopio, Antonio Passarino, Giuseppe Bellizzi, Dina Nutrients Article Natural compounds have historically had a wide application in nutrition. Recently, a fundamental role has been identified for essential oils extracted from aromatic plants for their nutritional, antimicrobial, and antioxidant properties, and as food preservatives. In the present study, essential oils (EOs) from ten aromatic plants grown in Calabria (Italy), used routinely to impart aroma and taste to food, were evaluated for their antibacterial activity. This activity was investigated against Escherichia coli strain JM109, and its derived antibiotic-resistant cells selected by growing the strain at low concentrations of ampicillin, ciprofloxacin, and gentamicin by measuring the minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC). Although all the essential oils showed bactericidal activity, those from Clinopodium nepeta, Origanum vulgare, and Foeniculum vulgare displayed the greatest inhibitory effects on the bacterial growth of all cell lines. It is plausible that the antibacterial activity is mediated by epigenetic modifications since the tested essential oils induce methylation both at adenine and cytosine residues in the genomes of most cell lines. This study contributes to a further characterization of the properties of essential oils by shedding new light on the molecular mechanisms that mediate these properties. MDPI 2022-01-17 /pmc/articles/PMC8780331/ /pubmed/35057572 http://dx.doi.org/10.3390/nu14020391 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article D’Aquila, Patrizia Paparazzo, Ersilia Crudo, Michele Bonacci, Sonia Procopio, Antonio Passarino, Giuseppe Bellizzi, Dina Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title | Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title_full | Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title_fullStr | Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title_full_unstemmed | Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title_short | Antibacterial Activity and Epigenetic Remodeling of Essential Oils from Calabrian Aromatic Plants |
title_sort | antibacterial activity and epigenetic remodeling of essential oils from calabrian aromatic plants |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8780331/ https://www.ncbi.nlm.nih.gov/pubmed/35057572 http://dx.doi.org/10.3390/nu14020391 |
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